TY  - JOUR
TT  - The Status of the P53 Gene and Human Papilluma Virus İnfection in Cervical Carcinoma  Patients
AU  - Shanehsazzadeh, Mehrnaz
AU  - Pourazar, Abbasali
AU  - Behbahanı, Mandana
PY  - 2012
DA  - July
JF  - Journal of Applied Biological Sciences
JO  - J.appl.biol.sci.
PB  - Anatolia Bilim Akademisi
WT  - DergiPark
SN  - 2146-0108
SP  - 9
EP  - 12
VL  - 6
IS  - 2
KW  - single-stranded conformation polymorphism
KW  - suppressor gene
KW  - HPV
KW  - PCR technique
KW  - Iranian women
N2  - Human papillomavirus (HPV) infections of the high-risk types are strongly linked to the development of cervical carcinoma. The HPV oncoproteins E6 and E7 are thought to play a crucial role in this process through their interactions with the P53 protein. E6 binds to P53 protein promoting its degradation. This is considered to contribute to the oncogenesis of HPV-associated anogenital cancer. On the other hand, in HPVnegative cervical carcinoma, P53 mutations are thought to have a role in the transformation process. In 25 formaldehyde-fixed paraffin embedded cervical carcinoma tissue samples were evaluated for the presence of HPV-DNA and mutations in exons 5-8 of the P53 gene by single-stranded conformation polymorphism analysis. Fourteen samples were HPV positive and only 3 missense point mutations were detected. These findings suggest that other mechanisms independent of P53 inactivation may play a role in the genesis of cervical carcinomas
UR  - https://dergipark.org.tr/en/pub/jabs/issue//387341
L1  - https://dergipark.org.tr/en/download/article-file/415635
ER  -