TY  - JOUR
TT  - A Comporative Study of Anticoagulant and Antiproliferative Activity of Fast  Moving Heparin From Giant Clam Tridacna maxima (Roeding,1798) and
AU  - Arumugam, Muthuvel
AU  - Balasubramanıan, Thangavel
AU  - Shanmugam, Annain
AU  - Garg, Hari
PY  - 2008
DA  - November
JF  - Journal of Applied Biological Sciences
JO  - J.appl.biol.sci.
PB  - Anatolia Bilim Akademisi
WT  - DergiPark
SN  - 2146-0108
SP  - 27
EP  - 30
VL  - 2
IS  - 3
KW  - antiproliferation
KW  - glycosaminoglycans
KW  - giant clam
KW  - green mussel
KW  - heparin
N2  - Heparin was isolated from two bivalve mollusks such as Tridacna maxima and Perna viridis. The isolated heparin was quantifi ed in crude as well as purifi ed samples and they were estimated as 2.72 & 2.2 gm / kg (crude) and 260 & 248 mg/gm (purifi ed) in T. maxima and P. viridis respectively. Both the bivalves shown the anticoagulant activity of the crude and purifi ed sample 20,128 USP units per kg and 7.4 USP units per mg and 39,000 USP units per kg and 75 USP units per mg and 9,460 USP units per kg and 4.3 USP units per mg and 13,392 USP units per kg and 54 USP units per mg correspondingly in T. maxima and P. viridis. The antiproliferative activity was studied with pulmonary artery smooth muscle cells (PASMC) using RPMI media reported that the result in a dose dependent manner. Among the two clams, P. viridis showed more antiproliferative activity than that of T. maxima
UR  - https://dergipark.org.tr/en/pub/jabs/issue//388022
L1  - https://dergipark.org.tr/en/download/article-file/416454
ER  -