@article{article_389621, title={Assessment of the Combined Effects of Acetamiprid and Propineb in Vivo}, journal={Journal of the Institute of Science and Technology}, volume={7}, pages={79–86}, year={2017}, author={Göç Rasgele, Pınar}, keywords={Mice bone marrow,micronucleus assay,mutagenicity,pesticide mixtur}, abstract={<p> <span class="fontstyle0">Pesticides are among commonly used chemicals in agriculture and are one of major environmental <br>pollutants. Acetamiprid and Propineb are widely used to control sucking insects and fungal infections on crops, <br>respectively. The study presented aimed to research genotoxic effects of mixture of Acetamiprid and Propineb, <br>in vivo. It was observed that mixture of Acetamiprid+Propineb increases the frequency of micronucleated <br>polychromatic erythrocytes (MNPCE) at all concentrations for 24 and 48 h depending on concentrations. But these <br>increases were not signifcant. The combined effect of the Acetamiprid and Propineb on bone marrow cells of <br>mice in vivo was found to be antagonistic in terms of percentage of MNPCE. In addition, mixture of Acetamiprid <br>and Propineb signifcantly decreased polychromatic erythrocytes/normochromatic erythrocytes (PCE/NCE) ratio <br>at all concentrations. The results of the present investigation revealed that Acetamiprid was non-genotoxic, while <br>mixture of the Acetamiprid and Propineb may have cytotoxic effects for mice bone marrow cells. But, additional in <br>vivo and in vitro mutagenicity studies measuring different levels of DNA damage are still necessary. </span> <br style=" font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "> </p>}, number={1}, publisher={Igdir University}