@article{article_390415, title={Effects of strontium ranilate and Hypericum perforatum extract on experimental colitis model in rats}, journal={Cumhuriyet Medical Journal}, volume={40}, pages={194–200}, year={2018}, DOI={10.7197/223.v40i37154.390415}, url={https://izlik.org/JA54KT75KH}, author={Kurt, Atilla and Soylu, Sinan and Şahin Inal, Zeynep Deniz and Serin, Musa}, keywords={Strontium,Hypericum perforatum,colit}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:200%;"> <b> <span style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;">Objective: </span> </b> <span style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;">
In this study, we aimed to compare the healing effect of strontium ranilate(SR)
and hypericum perfaratum (HPE) with the healing effect of prednisolone used in
the treatment of experimental colit in rats. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;vertical-align:middle;"> <b> <span style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;">Material
and Method </span> </b> <span style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;">: 30 wistar albino rats were used in the study. Rats
were randomly assigned to 5 consecutive groups consisting of 5 rats. Group 1,
healthy rats, group 2 colitis but untreated rats. The rats in groups 3, 4, and
5 had colitis and received 160 mg / kg SR, 1mg/kg prednisolone and  HP extracts containing 0.3% hiperisine (250
uq / 300 mg) by oral gavage, respectively for seven days. At the end of the
seventh day, the colons of the rats were removed and histopathological
examination was performed. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;vertical-align:middle;"> <b> <span style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;">Results </span> </b> <span style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;">:
The histopathological results of the HPE group were statistically worst
including the control group. It was observed that the best results in the
treatment groups were SR group followed by prednisolone group, respectively.(P<0.05) </span> </p> <p> </p> <b> <span style="font-size:12pt;line-height:115%;font-family:’Times New Roman’, serif;">Conclusion </span> </b> <span style="font-size:12pt;line-height:115%;font-family:’Times New Roman’, serif;">: This
study concluded that SR was at least as effective as prednisolone in colitis
treatment, but HPE exacerbate colitis-induced inflammation when received by
orally </span>}, number={2}