TY  - JOUR
TT  - Antiviral Therapy In Neonatal Cytomegalovirus Hepatitis And Cholestasis
AU  - Başarır Özkan, Tanju
PY  - 2005
DA  - June
JF  - Journal of Uludağ University Medical Faculty
JO  - Uludağ Tıp Derg
PB  - Bursa Uludağ University
WT  - DergiPark
SN  - 1300-414X
SP  - 103
EP  - 106
VL  - 31
IS  - 2
KW  - CMV
KW  - Neonatal hepatit
KW  - Kolestaz
KW  - Gansiklovir tedavisi
N2  - Neonatal hepatitis refers to a heterogenous group of disorders that result in a some what similar morphologic change in the liver of an  infant less than 3 months of age, in response to various insults, including cytomegalovirus infection. Neonatal hepatitis is responsible for  approximately 40% of the cases of infants with cholestasis. Cytomegalovirus may infect and replicate in both hepatocytes and cholangiocytes.  It may be cause latent or acut cholestatic or chronic hepatitis, including cirrhosis in immunocompatent infant too. It must be discussed  treatment choice with ganciclovir particularly in severe cases. In our center, 12 cases with CMV neonatal hepatitis were diagnosed  in betwen January 2003-January 2005. Group 1 was consisted of seven babies who were treated with ganciclovir during 21 days. Five  cases who were not given antiviral treatment were described as group 2. Physical examination, biochemical tests, antiviral serology were  done both groups at the time of diagnosis and repeated at the third month. This study revealed that ganciclovir treatment was safe and  efficient in the cholestatic hepatitis cases.
UR  - https://dergipark.org.tr/en/pub/uutfd/issue//391256
L1  - https://dergipark.org.tr/en/download/article-file/420559
ER  -