@article{article_391568, title={JAK-2 Gene Mutation in Essential Thrombocytosis and Relation with Complications}, journal={Journal of Uludağ University Medical Faculty}, volume={37}, pages={13–16}, year={2011}, author={Bayram, Murat and Özkocaman, Vildan and Özkalemkaş, Fahir and Ali, Rıdvan and Karkucak, Mutlu and Özçelik, Tülay and Irmak, Gönül and Yakut, Tahsin and Ocakoğlu, Gökhan and Aydın, Taner and et al.}, keywords={Essential thrombocytosis, JAK 2 gene mutation}, abstract={Essential thrombocytosis (ET) is a clonal disorder, within myeloproliferative diseases group, presenting with proliferation of megakaryocytes in bone marrow manifested clinically by overproduction of platelets that may cause bleeding and thrombosis or may be asympthomatic as well. About 50% of ET patients express the Janus Kinase 2 (JAK 2) gene mutation that may increase thrombosis and hemorrhage complications. In this study we aim to determine the frequency of JAK 2 gene mutation and to investigate the complications and relation of JAK 2 gene mutation with these complications in ET patients. Ninety patients, admitted to Division of Hematology, Department of İnternal Medicine, Uludag University School of Medicine between January 2005 and May 2010, diagnosed with ET and studied for JAK 2 gene mutation were investigated retrospectively. 58 (64.4%) of 90 patients was female and 32 (35.6%) was male. Average age was 55,4±14,9 (26-85) years. 38 (42.2%) of patients had positive JAK 2 gene mutation. The complication of hemorrhage and thrombosis had developed in 29 (32.2%) of patients. 21 (72.4%) of these patients had JAK 2 gene mutation. In conclusion, JAK 2 gene mutation is an important finding for diagnosis in ET patients and it may be related with complications.}, number={1}, publisher={Bursa Uludağ University}