@article{article_391575, title={Change in cerebral metabolism after CPAP in Obstructive Sleep Apnea Patients}, journal={Journal of Uludağ University Medical Faculty}, volume={37}, pages={27–32}, year={2011}, author={Coşkun, Funda and Karadağ, Mehmet and Gökalp, Gökhan and Hakyemez, Bahattin and Aydın, Birgül and Cangür, Şengül and Ursavaş, Ahmet and Erdoğan, Beril and Erdoğan, Cüneyt and Kırlı, Selçuk and et al.}, keywords={Sleep apnea, MR spectroscopy, Cognistat test}, abstract={Repeated apnea periods during sleep cause some changes on central nervous system in OSAS patients. MR spectroscopy is a noninvasive magnetic resonance method which can determine local metabolic changes in several situations that affect the central nervous system. In this study we aimed to determine the cerebral metabolic changes and whether there is an improvement in cerebral metabolism after continious positive positive airway pressure (CPAP) treatment in moderate-severe OSAS patients. We included 19 moderate-severe OSAS patients to the study. Polisomnography, epworth sleep scale, MR spectroscopy and neurocognitive tests were administered. CPAP treatment was given for 3 months, and MR spectroscopy, neurocognitive tests were repeated during this period. N-asetil aspartate (NAA), colin (Cho) ve creatinine (Cr) measurements was performed in frontal white matter, frontal cortex, talamus and hippocampus in MR spectroscopy. After the treatment, there was a significant reduction in frontal cortex Cr levels (p=0.046). Levels of NAA/Cho, NAA/Cr, Cho/Cr and NAA/Cho+Cr were compared and only NAA/Cr values in frontal white matter showed significant difference (p=0.01). As a result, we found that there are cerebral metabolic changes in moderate-severe OSAS patients and neurocognitive tests are associated with these changes.}, number={1}, publisher={Bursa Uludağ University}