TY - JOUR T1 - Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A Prospective Study TT - İntrauterin gelişme geriliği ile trombosit dağılım genişliği (PDW), platelet crit (PCT), ortalama trombosit hacmi (MPV) arasında bir ilişki var mı? Prospektif Bir Çalışma AU - Dayangan Sayan, Cemile AU - Yeral, Mahmut İlkin PY - 2018 DA - April DO - 10.21601/ortadogutipdergisi.391962 JF - Ortadoğu Tıp Dergisi JO - omj PB - MEDİTAGEM Ltd. Şti. WT - DergiPark SN - 2548-0251 SP - 51 EP - 56 VL - 10 IS - 1 LA - en AB - Aim: Intrauterinegrowth restriction (IUGR) is still an important pregnancy complication bringingon perinatal mortality and morbidity. Placental vascular dysfunction andsubsequent obliteration of placentalblood vessels are mostly accepted etiopathological factors ofintrauterine growth restriction similar with preeclampsia. We aimed toinvestigate the possible difference between pregnant women suffering fromintrauterine growth restriction and healty pregnant women for parameters ofplatelet count, platelet crit, platelet distribution crit and mean plateletvolume. Material and Methods:This case- control study was conducted with 179 pregnant women. The studypopulation was consisted of 94 pregnantwomen complicated with idiopathic IUGR(study group) and 85 healty pregnantwomen (control group). IUGR group wasdivided in two subgroups according to umbilical artery doppler velocimetrymeasurements. Complete blood count parameters including hemoglobin, plateletcount, plateletdistribution width (PDW), platelet crit(PCT), mean platelet volume (MPV) and white blood cellcount (WBC) were measured.Results:There was no significant difference between the groups for parameters ofhemoglobin, PC and PCT. The mean amniotic fluid index of IUGR group wassignificantly lower than the control group (p=0.000). The mean WBC, MPV and PDWlevels of IUGR group were significantly higher than the control group (p=0.013,p=0.047 and 0.035, respectively). The mean MPV level of IUGR group 1(umbilical artery S/D˃3)was significantly higher than that of IUGR group 2 (umbilical artery S/D<3)(p=0.045).Conclusions: In the present study, we observed a significant differencebetween IUGR and healty pregnant women for platelet parameters of MPV and PDW. Besidethis, we also observed higher MPV values in IUGR patients with increasedumblical artery resistance compared to that in IUGR patients with normalumblical artery blood flow. Further studies are needed to discuss our results. KW - Intrauterine growth restriction KW - pregnancy KW - platelet N2 - Amaç:İntrauterin gelişme geriliği(IUGR) günümüzde halen önemli bir gebelik komplikasyonu olup, perinatalmortalite ve morbiditeye neden olur. Plasental vasküler disfonksiyon ve bunutakiben plasental kan damarlarının obliterasyonu, preeklampsi ile benzerşekilde çoğunlukla intrauterin büyüme kısıtlamasının etyopatolojik faktörleriolarak kabul edilmektedir. Bu çalışmada intrauterin gelişme geriliği olangebeler ile sağlıklı gebeler arasındatrombosit sayısı, trombosit kriteri, trombosit dağılım kriteri veortalama trombosit hacmi parametreleri açısından olası farkın araştırılmasıamaçlandı.Gereçve Yöntemler: Bu vaka kontrolçalışması 179 gebe ile yürütülmüştür. Çalışma popülasyonu, idiyopatik İUGR ile komplikeolan 94 gebe (çalışma grubu) ve 85 sağlıklı gebeden (kontrol grubu)oluşmaktadır. IUGR grubu umbilikal arter doppler velosimetri ölçümlerine göreiki alt gruba ayrıldı. Hemoglobin, trombosit sayısı, PDW, PCT, PC, MPV ve beyazküre sayısı (WBC) gibi tam kan sayımı parametreleri ölçüldü.Bulgular: Hemoglobin, PC ve PCT parametreleri açısından gruplararasında anlamlı fark yoktu. IUGR grubunun ortalama amniotik sıvı indeksi kontrolgrubuna göre anlamlı derecede düşüktü (p = 0.000). IUGR grubunun ortalama WBC,MPV ve PDW değerleri kontrol grubundan anlamlı derecede yüksekti (sırasıyla p =0.013, p = 0.047 ve p= 0.035). IUGR 1. Grubunun (umbilikal arter S/D>3)ortalama MPV düzeyi IUGR 2. Grubununkinden (umbilikal arter S/D<3) anlamlıderecede yüksekti (p = 0.045). Sonuçlar:Bu çalışmada, MPV ve PDW değerleri açısından İUGR olan gebeler ile sağlıklı gebeler arasında anlamlı birfarklılık olduğunu gözlemledik. Bunun yanında, normal umblikal arter kanakımına sahip IUGR hastalarıyla karşılaştırıldığında, umblikal arter direncindeartış bulunan IUGR hastalarında MPV değerleri daha yüksekti. Sonuçlarımıztartışmak için yeni çalışmalara ihtiyaç bulunmaktadır. CR - 1. Dikbas L, Yapca OE, Dikbas N, Gundogdu C.Paraoxonase-2 and paraoxonase-3: comparison of mRNA expressions in the placentae of unexplained intrauterine growth restricted and noncomplicated pregnancies. 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