@article{article_392010, title={The Relationship Between Pre-treatment Serum Levels of AFP, CEA and CA 19-9 and Clinicopathological Factors in Patients with Locally Advanced and Metastatic Gastric Cancer}, journal={Journal of Uludağ University Medical Faculty}, volume={37}, pages={139–143}, year={2011}, author={Bayrak, Muharrem and Ölmez, Ömer Fatih and Kurt, Ender and Çubukcu, Erdem and Avcı, Nilüfer and Çubukcu, Sinem and Söker, Pınar and Manavoğlu, Osman}, keywords={Gastric cancer. Tumor markers. AFP. CEA. CA 19-9}, abstract={Pre-treatment serum levels of AFP, CEA and CA 19-9 were retrospectively investigated in 70 patients with locally advanced and metastatic gastric cancer. The positivity rates for these markers were 55.7%, 40% and 32.9%, respectively. Multiple logistic regression analysis for positive levels of tumor markers indicates that AFP positivity is significantly related to the presence of hepatic metastasis and resectability rates (p=0.041), CEA positivity is related to advance stage (p=0.011), tumor size (p=0.004), presence of hepatic metastasis (p=0.001), the frequency of serosal invasion (p=0.004) and resectability rates (p=0.011). Finally, CA 19-9 positivity is related to advance stage (p=0.006), tumor size (p=0.002), the frequency of serosal invasion (p=0.002), the frequency of peritoneal metastasis (p=0.005) and ascites (p=0.005). In summary, in cancer patients, the use of tumor markers for the decision of treatment might indicate the existence of any organ metastasis which could not be clinically or radiologically revealed.}, number={3}, publisher={Bursa Uludağ University}