TY  - JOUR
T1  - Endometrial Polipler ile Normal Endometriumda Estrogen ve Progesteron Reseptörlerinin Karşılaştırılması
TT  - Comparison of Estrogen and Progesterone Receptors in Endometrial Polyps and Normal Endometrium
AU  - Sakin, Önder
AU  - Yüksek, Şahin
AU  - Kars, Bülent
AU  - Çıkman, Muzaffer Seyhan
AU  - Anğın, Ali Doğukan
AU  - Şimşek, Engin Ersin
PY  - 2019
DA  - March
DO  - 10.16948/zktipb.392542
JF  - Zeynep Kamil Tıp Bülteni
PB  - Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH
WT  - DergiPark
SN  - 1300-7971
SP  - 13
EP  - 16
VL  - 50
IS  - 1
LA  - tr
AB  - AMAÇ: Endometrial poliplerin patogenezi halen tamolarak bilinmemektedir. Bu araştırmada amacımız endometrial poliplerdekisteroid reseptörlerini incelemektir.YÖNTEM: Buaraştırmada Şubat 2008 ile Aralık 2011 tarihleri arasında hastanemizde histeroskopik polipektomiyapılan 28 hastanın poliplerine ve sağlam endometrium dokularına ait östrojenve progesteron reseptörleri immunohistokimyasal olarak boyandı. Boyanmaskorları kuvvetli boyananlar için 3 pozitif, orta boyananlar için 2 pozitif vezayıf boyananlar için 1 pozitif olarak kaydedildi.BULGULAR: Östrojen reseptörleriendometriyal polip glandında 1 (%3.6) hastada zayıf, 17 (%60.7) hastadakuvvetli boyandı. Stromasında ise 5(%17.9) hastada zayıf, 12 (%52.8)hastada kuvvetli olarak boyandı. Polipin hemen yanındaki endometrial dokununglandında 13 (%46.4) hastada zayıf, 5 (%17.6) hastada kuvvetli boyandı.Stromasında ise 14 (%50.0) hastada zayıf, 3 (%10.7) hastada kuvvetli boyandı.Progesteronreseptörleri için endometriyal polip glandında zayıf boyanma olmadı. Kuvvetliboyanma 27 (%96.4) hastada görüldü. Stromasında da zayıf boyanma olmadı.Kuvvetli boyanma 25 (%89.3) hastada görüldü. Endometriyal polipin hemenyanındaki endometrium dokusunun glandında 4 (%14.3) hastada zayıf, 18 (%64.3)hastada orta, 6 (%21.4) hastada kuvvetli boyandı. Stromasında ise 3 (%10.7)hastada zayıf, 18 (%64.3) hastada orta, 7 (%25.0) hastada kuvvetliboyandı. SONUÇ: Bulgularımız steroidreseptörlerinin endometrial poliplerin gelişimi üzerine olan önemini desteklerniteliktedir. Bu reseptörlere yönelik geliştirilecek tedaviler hem polipleringelişiminin önlenmesinde, hem tedavisinde, hem de sebep olduğu şikâyetlerinengellenmesinde faydalı olabilecektir.
KW  - Polipler
KW  - östrojen reseptörü
KW  - progesteron reseptörü
N2  - INTRODUCTION: The pathogenesis of endometrial polyps is stillunknown. Our aim in this research is to examine steroid receptors inendometrial polyps. METHODS: This study immunohistochemically stained estrogen and progesteronereceptors of both polyp and intact endometrium tissues of 28 patients whounderwent hysteroscopic polypectomy between February 2008 and December 2011 inour hospital.RESULTS: The coloringscores were recorded as 3 positive for strong dyes, 2 positive for medium dyesand 1 positive for weak dyes. In endometrial polyp gland estrogen receptorswere weak in 1 (3.6%) patient and strong in 17 (60.7%) patient. In the stroma,5 (17.9%) patients were weak and 12 (52.8%) patients were strongly stained. Theendometrial tissues adjacent to the polyp 13 (46.4%) patients were weak and 5(17.6%) patients were strong stained. In the stroma, 14 (50.0%) patients wereweak and 3 (10.7%) patients were strongly stained.Progesterone receptors did not show weak staining on the endometrial polyp gland. Strong staining was observed in 27 patients (96.4%). There was no weak staining in stroma. Strong staining was observed in 25 patients (89.3%). The gland of the endometrial tissue adjacent to polyp; 4 (14.3%) patients weak, 18 (64.3%) moderate, and 6 (21.4%) patients were strong stained. In the stroma, 3 (10.7%) patients weak, 18 (64.3%) patients moderate and 7 (%25.0) patients were strongly stained.CONCLUSION: Our findings support the importanceof steroid receptors on the development of endometrial polyps. Therapeutictreatments for these receptors may be useful in preventing the development ofpolyps, as well as in treatment and prevention of complaints.
CR  - 1-Tanos V, Berry KE, Seikkula J, Abi Raad E, Stavroulis A, Sleiman Z, et al. The management of polyps in female reproductive organs. Int J Surg. 2017 Jul;43:7-16. doi: 10.1016/j.ijsu.2017.05.012. Epub 2017 May 5.
CR  - 2-Bel S, Billard C, Godet J, Viviani V, Akladios C, Host A, et al. Risk of malignancy on suspicion of polyps in menopausal women. Eur J Obstet Gynecol Reprod Biol. 2017 Sep;216:138-142. doi: 10.1016/j.ejogrb.2017.07.013. Epub 2017 Jul 15.
CR  - 3-Al Chami A, Saridogan E. Endometrial Polyps and Subfertility. J Obstet Gynaecol India. 2017 Feb;67(1):9-14. doi: 10.1007/s13224-016-0929-4. Epub 2016 Aug 20.
CR  - 4-Clark TJ, Stevenson H. Endometrial Polyps and Abnormal Uterine Bleeding (AUB-P): What is the relationship, how are they diagnosed and how are they treated? Best Pract Res Clin Obstet Gynaecol. 2017 Apr;40:89-104. doi: 10.1016/j.bpobgyn.2016.09.005. Epub 2016 Oct 1.
CR  - 5-Wong M, Crnobrnja B, Liberale V, Dharmarajah K, Widschwendter M, Jurkovic D. The natural history of endometrial polyps. Hum Reprod. 2017 Feb;32(2):340-345. doi: 10.1093/humrep/dew307. Epub 2016 Dec 18.
CR  - 6-Sant'Ana de Almeida EC1, Nogueira AA, Candido dos Reis FJ, Zambelli Ramalho LN, Zucoloto S. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polypsand adjacent endometrium in postmenopausal women. Maturitas. 2004 Nov 15;49(3):229-33.
CR  - 7-Zitao Liu, Kuokkanen S, Pal L. Steroid hormone receptor profile of premenopausal endometrial polyps. Reprod Sci. 2010 Apr;17(4):377-83. doi: 10.1177/1933719109356803.
CR  - 8-Gul A, Ugur M, Iskender C, Zulfikaroglu E, Ozaksit G. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polypsand its relationship to clinical parameters. Arch Gynecol Obstet. 2010 Mar;281(3):479-83. doi: 10.1007/s00404-009-1142-9. Epub 2009 Jun 9.
CR  - 9-Al-Azemi M, Labib NS, Motawy MM, Temmim L, Moussa MA, Omu AE. Prevalence of endometrial proliferation in pipelle biopsies in tamoxifen-treated postmenopausalwomen with breast cancer in Kuwait. Med Princ Pract. 2004 Jan-Feb;13(1):30-4.
CR  - 10-Antunes A Jr, Vassallo J, Pinheiro A, Leão R, Neto AM, Costa-Paiva L. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps: A comparison between benign and malignant polyps in postmenopausal patients. Oncol Lett. 2014 Jun;7(6):1944-1950. Epub 2014 Mar 28.
CR  - 11-Mittal K, Schwartz L, Goswami S, Demopoulos R. Estrogen and progesterone receptor expression in endometrial polyps. Int J Gynecol Pathol. 1996 Oct;15(4):345-8.
CR  - 12-Belisário MS, Vassallo J, Andrade LA, Alvarenga M, Pinto GA, Monteiro IM. The expression of the hormone receptors in the endometrium and endometrial polyps in postmenopausal women and its relationship to body mass index. Maturitas. 2006 Jan 10;53(1):114-8.
CR  - 13-Lopes RG, Baracat EC, de Albuquerque Neto LC, Ramos JF, Yatabe S, Depesr DB, et al. Analysis of estrogen- and progesterone-receptor expression in endometrial polyps. J Minim Invasive Gynecol. 2007 May-Jun;14(3):300-3.
CR  - 14-Van Dijk MM, van Hanegem N, de Lange ME, Timmermans A. Treatment of Women With an Endometrial Polyp and Heavy Menstrual Bleeding: A Levonorgestrel-Releasing Intrauterine Device or Hysteroscopic Polypectomy? J Minim Invasive Gynecol. 2015 Nov-Dec;22(7):1153-62. doi: 10.1016/j.jmig.2015.06.016. Epub 2015 Jul 4.
CR  - 15-Iatrakis G, Zervoudis S, Antoniou E, Tsionis C, Pavlou A, Kourounis G, et al. Is dosage of hormone replacement therapy related with endometrial polyp formation? Eur J Gynaecol Oncol. 2006;27(4):393-4.
CR  - 16-Dominick S, Hickey M, Chin J, Su HI. Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen. Cochrane Database Syst Rev. 2015 Dec 9;(12):CD007245. doi: 10.1002/14651858.CD007245.pub3.
CR  - 17-Yang JH, Chen CD, Chen SU, Yang YS, Chen MJ. Factors Influencing the Recurrence Potential of Benign Endometrial Polyps after Hysteroscopic Polypectomy. PLoS One. 2015 Dec 11;10(12):e0144857. doi: 10.1371/journal.pone.0144857. eCollection 2015.
UR  - https://doi.org/10.16948/zktipb.392542
L1  - https://dergipark.org.tr/en/download/article-file/802798
ER  -