@article{article_392996, title={Hypothermia and Hodgkin lymphoma in children}, journal={Pamukkale Medical Journal}, pages={67–70}, year={2016}, author={Köse, Doğan and Köksal, Yavuz and Çalışkan, Ümran}, keywords={child, Hodgkin, hypothermia, lymphoma}, abstract={Hypothermia associated with Hodgkin lymphoma is defined rarely. This may be caused by a dysfunction that shall occur in hypothalamus, central and peripheral vascular system, skin and muscles. In this study, two Hodgkin lymphoma cases with developed hypothermia are presented. Case 1: An “Hodgkin lymphoma, mixed cellular type” was diagnosed by a biopsy conducted due to lesions found in her spleen on a girl in 7 ages, who applied to the hospital with complaints such as fever, weight loss and night sweeting. While diagnostic works continued, the patient was administered regularly by paracetamol for fever. The ABVD (adriamycin, bleomycin, vincristine, dacarbazine) therapy protocol was begun on the patient. After chemotherapy was applied in first day, hypothermia developed on the patient, but this healed spontaneously approximately 5 days later without requiring a further therapy. Case 2: An “Hodgkin lymphoma, nodular sclerosing type” was diagnosed by a biopsy conducted by cervical lymph node on a girl in 9 ages, who applied to the hospital with complaints such as fever, itching and swelling on neck. While diagnostic works continued, the patient was administered regularly by paracetamol for fever. At this stage, hypothermia developed on the patient before the chemotherapy was applied. The ABVD therapy protocol was begun on the patient. Hypothermia healed spontaneously approximately 3 days later without requiring a further therapy. Hypothermia occurred in Hodgkin lymphoma depends probably on amount of generated endogen pyrogens and accordingly on personally changeable negative feedback threshold of the sensitized hypothalamus.}, number={1}, publisher={Pamukkale University}