TY  - JOUR
TT  - ADMINISTRATION OF DRUG VIA NASAL ROUTE
AU  - Özsoy, Yıldız
PY  - 2007
DA  - December
DO  - 10.1501/Eczfak_0000000541
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara University
WT  - DergiPark
SN  - 1015-3918
SP  - 267
EP  - 284
VL  - 36
IS  - 4
KW  - Nazal yol
KW  - nazal ilaç salımı
N2  - The nasal passage has become an administration route of systemic drugs as well, due to such advantages as its wide surface area, thin membrane property, low enzyme acitivity and highly vascularised structure. The nasal application of lipophilic drugs with low molecular weight yield absorption profiles close to i.v. administration. But high molecular weight and hydrophilic drugs have difficulty transferring through the nasal mucosa. Many strategies have been developed in order to improve this transport. Among them the most studied are bioadhesive polymer drug carrier systems. These systems increase absorption of drugs by prolonging the drug residence time in mucosa and by opening up tight junctions between the epithelial cells. In this review, the advantages and limitations of the nasal passsage, nasal anatomy, transport routes across nasal mucosa, improvement of drug permeation, systems prolonging the drug residence time in mucosa, and drugs/vaccines applied nasally and targeting to brain are briefly presented
UR  - https://doi.org/10.1501/Eczfak_0000000541
L1  - https://dergipark.org.tr/en/download/article-file/424415
ER  -