TY  - JOUR
TT  - SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME PYRIDINIUM  SALTS
AU  - Alptüzün, Vildan
AU  - Taşlı, Hüseyin
AU  - Erciyas, Erçin
PY  - 2006
DA  - September
DO  - 10.1501/Eczfak_0000000062
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - Ankara Ecz. Fak. Derg.
PB  - Ankara University
WT  - DergiPark
SN  - 1015-3918
SP  - 177
EP  - 188
VL  - 35
IS  - 3
KW  - Antimikrobiyal aktivite / Piridinyum tuzları / oksim eterler
N2  - Some pyridinium oxime ether derivatives comprising naphtyl, phytalimido, 2,6-dichlorophenyl and cyclohexyl rings linked to the ether function by a methylen bridge were synthesized and screened for possible antibacterial and antifungal activities using the microdilution method. Propyl and 3-phenylpropyl chains were chosen as side chains attached to the pyridinium nitrogen. Among these derivatives, NF-MFE containing naphtyl ring and 3-phenylpropyl chain exhibited highest antimicrobial activity against Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and Candida albicans in 312.5, 39.1, 9.8, 9.8 and 19.5 µg/ml concentrations respectively. The antimicrobial test results indicated that all the compounds have mild antibacterial activity against both Gram negative and Gram positive bacterial species. It can be hypothesized that bioactivity may be affected by electron density of pyridinium nitrogen atom and size of planar ring structure
UR  - https://doi.org/10.1501/Eczfak_0000000062
L1  - https://dergipark.org.tr/en/download/article-file/424464
ER  -