TY - JOUR TT - TEA TREE OIL: AS A PROMISING ANTIMICROBIAL AGENT AU - Tezgül Çakır, Nalan AU - Kaleağası, Sakine AU - Kökdil, Gamze PY - 2005 DA - December DO - 10.1501/Eczfak_0000000042 JF - Journal of Faculty of Pharmacy of Ankara University JO - J. Fac. Pharm. Ankara PB - Ankara University WT - DergiPark SN - 1015-3918 SP - 315 EP - 327 VL - 34 IS - 4 KW - Melaleuca alternifolia KW - çay ağacı yağı KW - antimikrobiyal KW - kimyasal bileşim KW - farmakolojik ve toksikolojik özellik N2 - Tea tree oil (TTO) is the essential oil steam distilled from leaves of the Australian native plant Melaleuca alternifolia (Myrtaceae), and has been used widely as a topical antiseptic in Australia for almost 80 years . Recent investigations have confirmed that tea tree oil exhibits broad spectrum antimicrobial activity which can be principally attributed to its high content of terpinen-4-ol. Recent clinical trials have shown promise. In the last fifteen years tea tree oil, as a naturally occurring agent, has become increasingly more popular for a wide range of pharmaceutical and cosmetic products. In this review; the identity, sources, composition, pharmacological properties of tea tree oil have been summarized. Also, the general toxicology profile of tea tree oil was discussed UR - https://doi.org/10.1501/Eczfak_0000000042 L1 - https://dergipark.org.tr/en/download/article-file/424498 ER -