TY  - JOUR
TT  - THE EFFECTS OF VITAMIN E TREATMENT ON TRACHEAL REACTIVITY  AND SOME BIOCHEMICAL PARAMETERS IN DIABETIC RATS
AU  - Ozansoy, Gülgün
PY  - 2003
DA  - December
DO  - 10.1501/Eczfak_0000000392
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara University
WT  - DergiPark
SN  - 1015-3918
SP  - 231
EP  - 241
VL  - 32
IS  - 4
KW  - Diyabet
KW  - trakea
KW  - vitamin E
KW  - sıçan
N2  - The present study investigated the effect of vitamin E treatment on the alterations in reactivity of trachea and some biochemical parameters in diabetic rat. Rats were randomly divided into two groups: Control and diabetic. Diabetes was induced by a single dose injection of streptozotocin (STZ; 60 mglkg ;i.p.). Diabetic rats were divided into two groups as untreated and treated with vitamin E. Vitamin E was given as a high-vitamin E diet in the standard laboratory chow diet (DL-_ tocophenyl acetate 0.5 % w/w) for 8 weeks started 8- week after induction of diabetes. In Vitamin E treated diabetic rats, the increased plasma triglyceride and thiobarbituric reactive substance levels due to diabetes were reduced without any effect on hyperglycemia. Vitamin E significantly restored the increased contractile responses to acetylcholine (ACh) and potassium chloride (KCl) in diabetic trachea. It is concluded that vitamin E treatment restored increased lipid peroxidation and tracheal reactivity in diabetic rat thus Vitamin E treatment may have beneficial effect on diabetic complications
UR  - https://doi.org/10.1501/Eczfak_0000000392
L1  - https://dergipark.org.tr/en/download/article-file/424625
ER  -