TY  - JOUR
TT  - Mathematical Investigation of In Vitro Diffusion Rate of a Drug From Ointmet Bases
AU  - İzgü, Enver
AU  - Ağabeyoğlu, İlbeyi
PY  - 1974
DA  - June
DO  - 10.1501/Eczfak_0000000205
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara University
WT  - DergiPark
SN  - 1015-3918
SP  - 0
EP  - 0
VL  - 4
IS  - 1
N2  - In this research, we have investigated the general in vitro diffusion profile from ointments. For this, we have used the agar gel and the filter paper methods in parallel. We have dealt with the results mathematically and tried to put thern into algebfaic equations. We have started from the work of LOCKIE and SPROWLS (35, 43). These researchers have found the diffusion in agalgel as Xz = k T. We have attacked the problem from a more general direction, by taking the equation as X = kTa We have established the constants for a number of ointment bases. After this, we have investigated the factors which influence these constants. The results are : a — As a general rule, salicylic acid diffuses from emulsion bases much more than` from hydrocarbon or oleaginous bases. The base, Mool. Alcohols Ointrnent BP 1968, gives very good diffusion in both methods. Same is true for the water soluble base, Veegum Base. b In the chromatographic method, the diffusion on filter paperfollows the parabolic relation X = kTa as determinçd by us. c — The role of HLB on the diffusion of salicylic acid seems to be nil with the agar gel method. However, HLB shows a definite influence with the filter paper method. Similar results are obtained on the investigation of the influence of water content. d — With the bases tested, the results obtained L-0m both of these methods seem to confirm each other. The correlation coefficient between the results is 0.71. This result is in a_ ccordance with the literature. e — The auxillarysubstances added to ointment bases increase the diffusion of salicylic acid. Those that are hydrophilic in nature, give higher diffusion than the hydrophobic ones. f — It is an easy matter to calculate the diffusion distance in advance, by means of the above mentioned algebraic equations. In this way, it seems possible to draw a scientific conclusion without consulting to experiments. In this research, we have established the equation constants.for some ointment bases with salicylic acid.
UR  - https://doi.org/10.1501/Eczfak_0000000205
L1  - https://dergipark.org.tr/en/download/article-file/425510
ER  -