TY  - JOUR
TT  - Uterin Leiomyosarkomlarda C-kit Pozitifliği İle Bcl-2 Artışı Arasındaki İlişki
AU  - Özçelik, Bülent
AU  - Akgün, Hülya
AU  - Serin, İbrahim S.
AU  - Başbu, Mustafa
AU  - Tayyar, Mehmet
PY  - 2004
DA  - April
JF  - Türk Jinekolojik Onkoloji Dergisi
JO  - TRSGO Dergisi
PB  - Türk Jinekolojik Onkoloji Derneği
WT  - DergiPark
SN  - 2148-5372
SP  - 59
EP  - 65
VL  - 7
IS  - 2
KW  - Leiomyosarkom
KW  - C-kit
KW  - Bcl-2
KW  - korelasyon
N2  - Objective: The proto-oncogene C-kit encodes for a transmembrane tyrosine kinase (KIT) receptor. Interaction with its ligand, stem cell factor, is essential in the development of many cells in human body. Especially in the hematopoietic stem cells could be protected from apoptosis as a result of KIT receptor activation which up-regulates bcl-2 expression. This study examines the ratio of C-kit expression in uterin leiomyosarcomas (LMS) and determines the correlation between C-kit expression and bcl-2 up-regulation. Materials and Methods: Archival tissue blocks from 10 patients with LMS and 10 leiomyoma (LM), which were randomly selected, were retrieved from pathology department. Normal myometrial tissues from patients with LM were determined and third group was constituted. Tissue samples were stained with monoclonal mouse antibody for bcl-2 and polyclonal rabbit antibody for Ckit. Avidin biotin immunoperoxidase method was employed for antibody detection. Staining intensity was graded 1+, 2+ or 3+ for bcl-2 and C-kit, staining distribution was graded as focal (10-30%), intermediate (30-60%) or diffuse (>60%) for C-kit. Results: C-kit was positive in 6 (%60), 1 (%10) and 0 (%0) of the LMS, LM and myometrium respectively. In the evaluation of groups in respect of C-kit staining, there was a significant immunopositivity (X2 value=11.5, p
UR  - https://dergipark.org.tr/en/pub/trsgo/issue//404287
L1  - https://dergipark.org.tr/en/download/article-file/438966
ER  -