TY  - JOUR
TT  - LOKAL İLERİ EVRE ENDOMETRİUM KANSERİNDE ADJUVAN RADYOTERAPİ: TEDAVİ SONUÇLARI VE PROGNOSTİK FAKTÖRLER
AU  - Bölükbaşı, Yasemin
AU  - Özsaran, Zeynep
AU  - Şengül, Adem
AU  - Meydan, Ahmet Deniz
AU  - Hanhan, Merih
AU  - Özsaran, Aydın
AU  - Aras, Arif
PY  - 2007
DA  - July
JF  - Türk Jinekolojik Onkoloji Dergisi
JO  - TRSGO Dergisi
PB  - Türk Jinekolojik Onkoloji Derneği
WT  - DergiPark
SN  - 2148-5372
SP  - 57
EP  - 64
VL  - 10
IS  - 3
KW  - Lokal ileri evre endometrium kanseri
KW  - radyoterapi
KW  - prognostik faktörler
N2  - Objective: To evaluate the efficacy of the adjuvant radiotherapy (RT) and to evaluate the prognostic factors for stage 3-4 endometrial cancer. Materials and Methods: Eighty-three patients with stage III-IV endometrial cancer treated with RT between 1997 and 2005 at Ege University Faculty of Medicine Department of Radiation Oncology were reviewed retrospectively. All patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH/ BSO), of these patients 63.9% had bilateral pelvic-paraaortic lymph node dissection and 7.2% had subtotal omentectomy. Patients were staged according to the 1988 FIGO staging system. All the patients received postoperative external RT (median dose: 50.4 Gy) and vaginal brachy-therapy. Chemotherapy were given in 43 (51.8) patients and hormonotherapy in 4.8% (4) either before or after RT . Results: Median age of the patients was 59 (range: 31-77) and 41 (49.4%) had Stage IIIA, 3 (3.6%) had Stage IIIB, 35 (42.2%) had Stage IIIC and 4 (4.8%) stage IVA disease. The predominat histopathology was adenocarcinoma (68.7%). Median follow-up was 62 months. Five years locoregional local control, disease free survival and overall survival were 66.2%, 46.2%, 91.8% and 56%, respectively. Statistical analysis revealed that number of extrauterine disease (p=0.005) and cervical extension invasion (p=0.05) were predictive factors for overall survival and for disease free survival prognostic factor were histologic grade (p=0.032) and number of extrauterine disease (p=0.007). Conclusion: Postoperative adjuvant radiotherapy provides locoregional control rates with acceptable toxicity in patients with local advanced endometrial carcinoma.
UR  - https://dergipark.org.tr/en/pub/trsgo/issue//404438
L1  - https://dergipark.org.tr/en/download/article-file/439189
ER  -