@article{article_406372, title={THE EFFECTS OF VERAPAMIL, A CALCIUM CANAL BLOKER, ON CISPLATIN TOXICITY}, journal={Journal of Science and Technology of Dumlupınar University}, pages={15–26}, year={2008}, author={Dikmen, M. and Başaran, A.}, keywords={Cisplatin,Rat,Toxicity,Verapamil}, abstract={ The aim of this study was investigated to protective effects of calcium chanel blocker verapamil on cisplatin induced toxicity. Fourty-two Rattus norvegicus (Wistar albino) rats were divided into six groups. The control group (I. group) was injected with 0.3 ml saline, II. group was injected with 0.2 mg/kg verapamil, III. group was injected with  2 mg/kg verapamil, IV. group was injected with 5 mg/kg cisplatin, V. group was injected with 0.2 mg/kg verapamil+5 mg/kg cisplatin and VI. group was injected with 2 mg/kg verapamil+5 mg/kg cisplatin. Before cisplatin injection, verapamil was given during the three days at the same hour. After this period, at the fourth day, cisplatin was injected with as a single dose. Following the last dose, within 24 hours urine samples were collected and than blood, kidney and liver tissues samples and bone marrow were collected from the rats under ether anesthesia. At the end of the study, we found that serum creatinine in the IV. group was significantly increased according to control group (p<0.001). SGOT activity was significantly decreased in III., V. and VI. groups (p<0.001). As a result of chromosomal analyses,   there were not significantly increased on the number of chromatid typed gaps in the IV., V ve VI. group according to control group. Histopathologic findings showed that a certain recovery was dedected into  kidney tissue of the V. group according to kidney tissue of  IV.group . As a conclusion, it was determined that verapamil had a protective effect on cisplatin toxicity and this protective effect was   high   in the V. group which had been given low dose of verapamil.  }, number={015}, publisher={Kütahya Dumlupinar University}