@article{article_407628, title={The relationship between I-131 uptake in postoperative residue thyroid tissue and absorbed doses calculated with MIRDOSE3 and pre-ablation thyroglobulin levels in patients with differential thyroid cancer: A retrospective comparison study}, journal={Cumhuriyet Medical Journal}, volume={40}, pages={43–49}, year={2018}, DOI={10.7197/223.vi.407628}, url={https://izlik.org/JA99RR49GP}, author={Demir, Fadime and Hasbek, Zekiye and Erselcan, Taner and Turgut, Bülent}, keywords={I-131,thyroglobulin,thyroid cancer}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">Objective: </span> </b> <span style="font-size:10pt;font-family:’Times New Roman’, serif;">The aim of this
study was to compare I-131 uptake in postoperative residue thyroid tissue and
absorbed doses calculated with MIRDOSE3 and pre-ablation thyroglobulin levels
in patients with differential thyroid cancer and was to investigate whether
there is a relationship in terms of effectiveness to treatment efficacy.  </span> <b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </b> </p> <p> <b> </b> </p> <b> </b> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">Method: </span> </b> <span style="font-size:10pt;font-family:’Times New Roman’, serif;">Seventy-four patients were included in the
study. Serum thyroglobulin and thyroid stimulating hormone levels before
ablation were measured in patients. Uptake values were calculated using I-131
whole body scan scintigraphy images taken on the 8th day after ablation. The
findings were evaluated with low dose I-131 whole body scan scintigraphy at
8th-12th months after ablation. Also the effective half-life of I-131,
cumulative activity and I-131 residence time were calculated for each patient.
The values found were used in the MIRDOSE3 program to calculate total body
absorptive doses and comparison was made between the parameters. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">Results: </span> </b> <span style="font-size:10pt;font-family:’Times New Roman’, serif;">Thyroglobulin values and uptake values
were compared with sperman analysis. There was intermediate correlation between
them (r = 0.616, p = 0.01). There was a low correlation in the negative
direction between thyroid stimulating hormone levels and uptake values of
patients before ablation (r =-0.218, p = 0.05). In 74 patients 8th-12th. Month
whole body scan scintigraphy and thyroglobulin results are evaluated; 3 (4.1%)
patients were not complete ablated and 71 patients (95.9%) were complete
ablated. There was a significant difference only in the thyroglobulin value
between complete ablated and non-ablated patient groups (p =0.001). There was a
low correlation between absorbed doses and thyroglobulin values (r = 0.212, p =
0.05). </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:normal;"> <b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">Conclusions: </span> </b> <span style="font-size:10pt;font-family:’Times New Roman’, serif;">As a result, we observed that
thyroglobulin values measured before I-131 treatment inform about residual
tissue after surgery and residual tissue size may affect treatment efficacy. We
also think that attention should be paid to the treatment and follow-up
protocol in terms of complete ablation success in patients with high
pre-treatment thyroglobulin values. </span> </p> <p> </p>}, number={1}