TY  - JOUR
T1  - The Treatment of Infectious Bovine Keratoconjunctivitis Under Field Conditions: Intrapalpebral Injection Versus Subconjunctival Injection of Oxytetracycline
TT  - Saha Koşullarında Enfeksiyöz Bovine Keratokonjuktivitis’in Sağaltımı: Subkonjuktival Oksitetrasiklin Enjeksiyonuna Karşı İntrapalpebral Enjeksiyon
AU  - Borum, Ayşe Ebru
AU  - Çeçen, Göksen
AU  - Akın, İbrahim
PY  - 2018
DA  - September
Y2  - 2018
DO  - 10.30607/kvj.408380
JF  - Kocatepe Veterinary Journal
JO  - kvj
PB  - Afyon Kocatepe University
WT  - DergiPark
SN  - 1308-1594
SP  - 232
EP  - 237
VL  - 11
IS  - 3
LA  - en
AB  - Thepurpose of this study was to determine the efficacy of oxytetracyclinewhen applied intrapalpebral (IPa) injection to the eye, compared withsubconjunctival (SCo) injection, in the treatment of infectious bovinekeratoconjunctivitis (IBK). Twenty eyes with severe clinical signs of IBK, of15 Holstein Friesian female cattle aged 2–4 years were evaluated in this study.The affected animals had unilateral (n=10; 66.7%) and bilateral (n=5; 33.3%)symptoms. Moraxella bovis wereidentified in all ocular swabs samples on day 0 and all isolates weresusceptible to oxytetracycline (100%).Oxytetracycline (100 mg/ml) was injected IPa (n=10) and SCo (n=10) at atotal dose of 200 mg once daily on days 0, 3 and 6. After injections, theanimals were re-examined for resolution of lesions associated with IBK weeklyuntil the corneal ulcer healed. Microbiologic examination was repeated 3 timesat intervals of 1 week. There is no effect of injection type on healing time ofthe lesion. Size and side of the lesion have a significant effect on healingtime (p<0.001). It was found that small lesions had earlier clean in termsof the microbiologic evaluation. Lesion size has a significant effect onmicrobial growth (p<0.001). In conclusion, the same therapeutic effect wasachieved in both applications. However, oxytetracycline given by IPainjection was comparatively easy, more comfortable and less invasive especiallyfor painful eyes against IBK than SCo injection under the conditions of thisstudy. In addition, it was enough for cattle with IBK at the dosage (200 mg,once daily on days 0, 3 and 6) of used in the study.
KW  - cattle
KW  - IBK
KW  - intrapalpebral
KW  - oxytetracycline
N2  - Bu çalışmanın amacı,infeksiyöz bovine keratokonjuktivitis (IBK)’in sağaltımında, gözeintrapalpebral (IPa) enjeksiyon ile uygulanılan oksitetrasiklin’in,subkonjuktival (SCo) enjeksiyon ile karşılaştırıldığındaki etkinliğinibelirlemekti. Çalışmada, IBK’nın şiddetli klinik bulguları bulunan 2-4yaşındaki, dişi, 15 Holstein Friesian sığıra ait 20 göz değerlendirildi.Etkilenen hayvanlar unilateral (n=10; % 66,7) ve bilateral (n=5; % 33,3)semptomlara sahipti. 0. günde tüm oküler swab örneklerinden Morexella bovis izole edildi veoksitetrasikline duyarlı idi (% 100). 0, 3 ve 6. günlerde günde bir kez toplam200 mg dozda oksitetrasiklin (100 mg/ml) IPa (n=10) ve SCo (n=10) olarakenjekte edildi. Enjeksiyonlardan sonra, korneal ülser iyileşmesi şekilleninceyekadar haftalık olarak IBK ile ilişkili lezyonlar yönünden hayvanlar tekrar muayeneedildi. Mikrobiyolojik muayene birer hafta ara ile 3 kez tekrarlandı. Lezyonuniyileşme zamanı üzerine enjeksiyon tipinin etkisi yoktu. Lezyonun büyüklüğü vebulunduğu tarafın iyileşme zamanı üzerine belirgin etkisi vardı (p<0.001).Küçük lezyonlar mikrobiyolojik değerlendirmede daha erken dönemde temizbulundu. Lezyon büyüklüğü mikrobiyal gelişimi belirgin olarak etkiledi(p<0.001). Sonuç olarak, her iki uygulama ile aynı terapötik etki sağlandı.Bununla birlikte, bu çalışmada saha koşullarında özellikle ağrılı gözlerde IPaenjeksiyon yolu ile verilen oksitetrasiklin, SCo enjeksiyondan nispeten dahakolay, daha rahat ve daha az invazivdi. İlave olarak, bu çalışmada kullanılandoz (0, 3 ve 6. günlerde günde bir kez 200 mg) IBK’lı sığırlar için yeterliidi.
CR  - Alexander D. Infectious bovine keratoconjunctivitis: A review of cases in clinical practice. Vet Clin North Am Food Anim Pract. 2010; 26: 487-503.
CR  - Angelos JA, Hess JF, George LW. Cloning and characterization of a Moraxella bovis cytotoxin gene. Am J Vet Res. 2001; 62: 1222-1228.
CR  - Bedford PGC. Ocular diseases. 917-926. In: Andrews AH, Blowey RW, Boyd H et al. (Eds.), Bovine Medicine. 2nd ed. London, 2004; Blackwell Scientific Publications.Angelos JA. Infectious Bovine Keratoconjunctivitis (Pinkeye). Vet Clin Food Anim. 2015; 31: 61–79.
CR  - Cullen JN, Yuan C, Totton S, Dzikamunhenga R, Coetze JF, da Silva N, Wang C, O’Connor AM  A systematic review and meta-analysis of the antibiotic treatment for infectious bovine keratoconjunctivitis: an update. Anim Health Res Rev. 2016; 17(1): 60-75.
CR  - Burns M, O’Connor A. Assessment of methodological quality and sources of variation in the magnitude of vaccine efficacy: a systematic review of studies from 1960 to 2005 reporting immunization with Moraxella bovis vaccines in young cattle. Vaccine. 2008; 26(2): 144-152.
CR  - Zielinski GC,  Piscitelli HG,  Perez-Monti H, Stobbs LA, Zimmermann AG. Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye). Vet Ther. 2002; 3(2): 196-205.
CR  - Brown MH, Brightman AH, Fenwick BW, Rider MA. Infectious Bovine Keratoconjunctivitis: A Review. J Vet Intern Med. 1998; 12: 259-266.
CR  - McConnel CS, Shum L, House JK.  Infectious bovine keratoconjunctivitis antimicrobial therapy. Aust Vet J. 2007; 85(1-2), 65-69.
CR  - George LW, Wilson WD, Baggot JD, Mihalyi JE. Antibiotic treatment of Moraxella bovis infection in cattle. J Am Vet Med Assoc. 1984; 185(10): 1206-1209.
CR  - George LW,  Smith JA,  Kaswan R. Distribution of oxytetracycline into ocular tissues and tears of calves. J Vet Pharmacol Ther. 1985; 8(1): 47-54.
CR  - Senturk S, Cetin C, Temizel M, Ozel E. Evaluation of the clinical efficacy of subconjunctival injection of clindamycin in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Vet Ophthalmol. 2007; 10(3): 186-189.
CR  - Quinn PJ, Cater ME, Markey BK, Carter CR. Clinical Veterinary Microbiology. London, Wolfe-Mosby. 1994; 284-286.
CR  - Gokce I, Citil M, Genc O, Kankavi O. A comparison of the efficacy of florfenicol and oxytetracycline in the treatment of naturally occurring infectious bovine keratoconjunctivitis. Ir Vet J. 2002; 55(11): 573-576.
CR  - Pickett JP. Eye Disease. In: Howard JL, Smith RA (Eds.). Current Veterinary Therapy Food Animal Practice. 4th Ed, Saunders. 1999; 633-657.
CR  - Prieto C, Serra DO, Martina P, Jacobs M, Bosch AM, Yantorno OM. Evaluation of biofilm-forming capacity of Moraxella bovis, the primary causative agent of infectious bovine keratoconjunctivitis. Vet Microbiol. 2013; 166(3-4): 504-15.
CR  - Shryock TR, White DW, Werner CS. Antimicrobial susceptibility of Moraxella bovis. Vet Microbiol. 1998; 61: 305-309.
CR  - Zielinski G, Piscitelli H, Perez-Monti H, Stobbs LA. Antibiotic sensitivity of an Argentine strain collection of Moraxella bovis. Vet Ther. 2000; 1: 199-204..
UR  - https://doi.org/10.30607/kvj.408380
L1  - https://dergipark.org.tr/en/download/article-file/541593
ER  -