@article{article_409714, title={Seroprevalence of Celiac Disease in Patients with Presumed Diagnosis of Diarrhea Predominant Irritable Bowel Disease}, journal={Journal of Human Rhythm}, volume={4}, pages={44–51}, year={2018}, author={Aktaş, Ezgi and Ayaz, Teslime and Rakici, Halil and Tüfekçi, Damla and Ozyurt, Neslihan}, keywords={diarrhea predominant IBS,celiac disease,serology,anti-tissue transglutaminase antibody,endomysial antibody}, abstract={<p>Object This study aims to determine seroprevalence of celiac disease (CD) in patients with presumed diarrhea predominant irritable bowel <br />disease (IBS-D). <br />Methods A total of 100 patients with presumed IBS-D (mean(SD) age: 42.8(16.8) years, 64.0% were females) were included in this crosssectional single-centre study. Data on patient demographics, smoking status, co-morbid psychiatric disorders and blood biochemistry <br />were recorded. Seroprevalence of CD specific anti-tissue transglutaminase (anti-tTG) antibodies (anti-tTG IgA and anti-tTG IgG) and <br />endomysial (EMA) antibody were determined, while demographic characteristics and laboratory findings were compared between CD <br />seronegative and seropositive patients. <br />Results Anti-tTG IgG antibody was positive in 17.0% of patients, as followed by anti-tTG IgA antibody positivity in 7.0% and anti-EMA antibody <br />positivity in 12.0% of patients. Positive findings for at least one antibody was noted in 17(17.0%) patients including positivity for single <br />antibody in 3(3.0%) patients, two antibodies in 9(9.0%) patients and three antibodies in 5 (5.0%) patients. No difference was noted <br />between seropositive and seronegative patients in terms of gender, active smoking, co-morbid psychiatric disorder and laboratory <br />findings. <br />Conclusion In conclusion, our findings revealed that non-negligible percentage of patients with suspected IBS-D had positive serological findings <br />for CD and thereby emphasize that “test and treat” strategy for CD in patients with presumed IBS-D may be worthwhile. <br /> </p>}, number={1}, publisher={Ramazan AKDEMİR}