@article{article_412070, title={Effect Of Astaxanthin On Rat Brains Against Oxidative Stress Induced By Cadmium:Biochemical, Histopathological Evaluation}, journal={Journal of the Institute of Science and Technology}, volume={8}, pages={33–39}, year={2018}, DOI={10.21597/jist.412070}, author={Akkoyun, Hürrem Turan and Bengu, Aydin Sukru and Ulucan, Aykut and Bayramoglu Akkoyun, Mahire and Ekin, Suat and Temel, Yusuf and Çiftçi, Mehmet}, keywords={Astaxanthin,cadmium,oxidative stress}, abstract={<p>Aim of this study is to evaluate protective impact of Astaxanthin (AST) on rats with experimental </p> <p>brain injury induced with Cadmium (Cd). 32 male Wistar albino rats were divided into four groups as Control, </p> <p>Cadmium, Astaxanthin (AST), Cadmium (Cd)+Astaxanthin (AST). Rat brain tissues were obtained at the end </p> <p>of 30th day. Malondialdehyde (MDA), glutathione (GSH) levels and superoxide dismutase (SOD) enzyme </p> <p>activities were measured in brain homogenates and histopathological examination was performed. MDA levels </p> <p>were improvement in cadmium administered group (p<0.01) as well as Cd+AST administered group (p<0.05) </p> <p>compared to control group. In addition a substantial reduction Cd+AST group was observed compared to cadmium </p> <p>administered group (p<0.01). GSH level shows a decrease in Cd and Cd+AST groups compared to control (p<0.05). </p> <p>SOD enzyme activity was found significantly lower in Cd and Cd+AST groups compared to control (p<0.01). In </p> <p>addition, increase of SOD in Cd+AST group compared to cadmium group was also found significant (p<0.05). </p> <p>Histopathological findings in the cerebral cortex and hippocampus were different between groups. In the control </p> <p>and AST administered groups, normal histological structure was observed in the brain, while severe lesions were </p> <p>seen in the Cd administered group and in the Cd+AST group only mild degenerative lesions were observed. </p> <p>As a result, elevated MDA level due to Cd administration was attenuated with AST administration. Decreased GSH </p> <p>level and SOD enzyme activity due to Cd administration was increased with AST administration. In addition, AST </p> <p>administration decreased histopathological lesions. Consequently, it is thought that AST may be used for protection </p> <p>against brain oxidative damage due to Cd. </p>}, number={4}, publisher={Igdir University}