TY  - JOUR
T1  - Bone mineral density in obese children with prediabetes
TT  - Prediyabeti olan obez çocukların kemik mineral dansitometreleri
AU  - Üstyol, Ala
AU  - Atabek, Mehmet Emre
PY  - 2018
DA  - June
DO  - 10.19161/etd.414976
JF  - Ege Tıp Dergisi
JO  - EJM
PB  - Ege University
WT  - DergiPark
SN  - 1016-9113
SP  - 94
EP  - 99
VL  - 57
IS  - 2
LA  - en
AB  - Aim: Theaim of this study was to evaluate the relationships between bone mineraldensity (BMD) vs metabolic risk factors in obese adolescents withprediabetes.Materials and Methods: A total of 131 obese children and adolescents, aged 6-18 years of agewere enrolled the study. Prediabetes was determined by a fasting blood glucoselevel of ≥100 to 125 mg/dL or 2-hour oral glucose tolerance test value of ≥140to 199 mg/dL. Five patients who were diagnosed as having type 2 diabetes wereexcluded and remaining participants were classified as normal glucose tolerance(NGT) and prediabetic. BMD was measured on calcaneus using quantitativeultrasound. BMD and metabolic parameters were investigated and compared inthese two groups.Results: Therewas no significant difference in BMD between children and adolescents withprediabetes (n = 37) or NGT (n = 89). The parameters of prediabetes did notaffect BMD and these results did not change when we adjusted for weight,height, age, sex, pubertal status. The multivariate linear regression analysisrevealed that the only independent factor associated with higher BMD was higherBMI (OR=0.007 95%CI 0.002-0.013 p=0.013). No significant associations werefound between BMD and waist circumference or biochemical measurements.Conclusion: Plasma glucose within theprediabetic range is not associated with bone mineral density in obesechildren. Thus, the positive association of BMI with BMD may be by means ofalternative pathways.
KW  - Bone mineral density
KW  - obesity
KW  - prediabetes
KW  - children.
N2  - Amaç: Çalışmanınamacı prediyabetik obez çocuk ve ergenlerde kemik mineral dansitometresinin(KMD) metabolik faktörlerle ilişkisini araştırmaktır.Gereç ve Yöntem: Çalışmaya 6-18 yaş arasında 131 adet çocuk ve ergen dahil edildi.Prediyabet kriteri açlık kan glikozunun ≥100-125 mg/dL aralığında olması yadaglikoz yükleme testi 2. saat glikoz değerinin ≥140-199 mg/dL arasında olmasıolarak belirlendi. Bu ölçütlere göre tip 2 diyabet tanısı alan 5 hasta çalışmadışı tutulurken geri kalanlar prediyabet ve normal glikoz toleranslı (NGT)hastalar olmak üzere iki guruba ayrıldılar. KMD kalkaneustan kantitatifultrason ölçüm cihazı ile yapıldı. Her iki grupta KMD ve metabolik parametrelerkarşılaştırıldı.Bulgular: Gruplar arasında KMD açısından anlamlı bir fark yoktu. Prediyabetölçütleri KMD‘yi etkilemiyor üstelik ağırlık, boy, yaş, cinsiyet ve ergenlikgibi KMD üzerine olası etkileri olabilecek parametrelere göre düzenlemesonrasında bu durum değişmiyordu. Lineer regresyon analizinde beden kitleindeksi (BKİ) ile KMD arasında pozitif ilişki bulundu. Bel çevresi ve diğermetabolik faktörler ile KMD arasında ise bir ilişki bulunamadı.Sonuç: Prediyabetik aralıktaki glikozdeğeri ile KMD arasında herhangi bir ilişki yoktur. Obez çocuklarda fazla BKİile KMD arasındaki pozitif korelasyonu açıklayacak bilinen metabolikparametreler dışında alternatif etkenler olabilir.
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UR  - https://doi.org/10.19161/etd.414976
L1  - https://dergipark.org.tr/en/download/article-file/457255
ER  -