TY  - JOUR
T1  - Küçük hücreli dışı akciğer karsinomlarında tümör ilişkili makrofajların tümör progresyonundaki rolü
TT  - The role of tumor-associated macrophages on tumor progression in non-small cell lung carcinoma
AU  - Tepeoğlu, Merih
AU  - Taştepe, F.zeynep
AU  - Özdemir, B.handan
PY  - 2018
DA  - June
DO  - 10.19161/etd.415007
JF  - Ege Tıp Dergisi
JO  - ETD
PB  - Ege University
WT  - DergiPark
SN  - 1016-9113
SP  - 107
EP  - 112
VL  - 57
IS  - 2
LA  - tr
AB  - Amaç: Akciğer kanseri tüm dünyada kanserden ölümlerin en sık sebebidir. Küçükhücreli dışı akciğer karsinomları (KHDAK) da en sık görülen akciğer kansertipidir. Bu çalışmada küçük hücreli dışı akciğer karsinomlarında, tümörilişkili makrofajların (TAM) tümör progresyonu ve metastaz üzerindeki etkileriaraştırıldı.Gereç veYöntem: Ocak 2011 ile Mayıs 2016 tarihleri arasındaBaşkent Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalında KHDAK tanısı alan80 olgu çalışmaya dahil edildi. Olguların klinik takip bulguları kaydedildi vetüm olgulara immünhistokimyasal olarak CD 68 antikoru uygulandı.Bulgular: Olguların 36’sı (%45) skuamöz hücreli karsinom (SHK), 36’sı (%45)adenokarsinom, 6’sı (%7.5) büyük hücreli karsinom ve 2’si de (%%2.5)adenoskuamöz karsinom idi. Yapılan immünhistokimyasal çalışma sonucunda, 28olgunun (%35) tümör dokusunda 1+, 21 olgunun (%26.3) tümör dokusunda 2+ ve 31olgunun (%38.8) tümör dokusunda ise 3+ TAM yoğunluğu izlendi. Evre 1 olan 32hastanın yalnızca 1 tanesi (%3.1) 3+ TAM yoğunluğuna sahipken, evre 2 olan 32hastanın 17’sinde (%53.1) ve evre 3+4 olan 16 hastanın ise 13’ünde (%81.3) 3+TAM yoğunluğu saptandı. TAM yoğunluğu 1+ olan hastaların ortalama yaşam ömrü 39.7±17.4ay iken, TAM yoğunluğu 2+ olan hastaların 36.6±17.1 ay ve TAM yoğunluğu 3+ olanhastaların ise 27.3±18.4 aydı (p<0.05).Sonuç: Bu çalışmada, patolojik T evresi ve TNM evresi yüksek olan KHDAK’da TAMsayısının daha yüksek olduğu görüldü ve yüksek TAM sayısı olan hastalarınortalama sağkalım süresinin de, düşük TAM sayısı olan hastaların sağkalımsüresinden kısa olduğu saptandı.
KW  - Akciğer
KW  - küçük hücreli dışı akciğer karsinomu
KW  - tümör ilişkili makrofaj.
N2  - Aim: Lungcancer remains the leading cause of cancer-related mortality in all over theworld. Non-small cell lung cancer (NSCLC) is the most frequent type of lungcarcinoma. In the current study, the effects of tumor-associated macrophages(TAM) on tumor progression and metastasis in NSCLC were investigated.Materialsand Methods: Eighty NSCLC cases, which were diagnosed in BaşkentUniversity Medical School, Department of Pathology between January 2011 and May2016 were included into the study. Clinical follow-up findings of the patients wererecorded and CD68 immunohistochemistry was performed to all of them.Results: Histologically, 36 cases (45%) were squamous cell carcinoma, 36 cases(45%) were adenocarcinoma, 6 cases (7.5%) were large cell carcinoma, and 2cases were adenosquamous carcinoma (2.5%). The density of TAM in tumor tissue was1+ in 28 cases (35%), 2+ in 21 cases (26.3%) and 3+ in 31 (38.8%) cases byimmunohistochemistry. In addition, the density of TAM was 3+ in only 1 (3.1%)of 32 stage 1 patients, 17 (53.1%) of 32 stage 2 and 13 (81.3%) of 16 stage 3and 4 patients had 3+ TAM density. The average survival was 39.7±17.4 months,36.6±17.1 months and 27.3±18.4 months respectively (p<0.05), in the thepatients who had 1+, 2+ and 3+ TAM density.Conclusion:In the current study, we detected that the numberof TAM is higher in NSCLC patients who had higher pathological T and TNM stage.Also, an average survival of the patients who had a higher number of TAM wasshorter than the patients who had a lower number of TAM.
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UR  - https://doi.org/10.19161/etd.415007
L1  - https://dergipark.org.tr/en/download/article-file/457323
ER  -