@article{article_416012, title={The role of COX-2 gene variants on the disease mechanism of inflammatory bowel disease in a Turkish population}, journal={Archives of Clinical and Experimental Medicine}, volume={3}, pages={45–48}, year={2018}, DOI={10.25000/acem.416012}, author={İplik, Elif Sinem and Kahraman, Resul and Ertuğrul, Barış and Candan, Gonca and Ergen, Arzu and Çakmakoğlu, Bedia}, keywords={COX-2,gene variants,Crohn’s disease,Ulcerative Colitis}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Aim: Inflammatory
bowel disease has two major types: Crohn’s disease and ulcerative colitis that
occur in the gastrointestinal tract with unknown etiology. COX-2 has important
role on carcinogenesis process including colon cancer supporting the tumor
growth. COX-2 was also known due to its ability to change homeostasis on
colonic mucosa in inflammatory cells on patients who have inflammatory bowel
disease.  In this study, we have aimed to
find a linkage between inflammatory bowel disease and COX-2 in a Turkish population. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Methods:A total of 106 patients,42 with </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Crohn’s disease </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">
and 64 with </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">ulcerative
colitis </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> and 121 healthy control subjects were
included the study. </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Gene
variants of <a>COX-2-765G→C and COX-2-1195A→G </a> were </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">analyzed
by polymerase chain reaction and restriction fragment length polymorphism
techniques. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Results: The
results demonstrated that COX-2-1195A→G gene variants AA carriers were
statistically found in high level on patients with both ulcerative colitis
(p=0,001) and Crohn’s disease ( </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">p=0.008 </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">). In contrast, AG genotype and G carriers
were statistically found higher in control group (Crohn’s disease, </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">p=0.005
for AG and p= 0.008 for G; ulcerative colitis, p=0.001 for AG and p=0.001 for
G). </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:200%;"> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Conclusion: In this research, we have
observed important and questionable results between </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">inflammatory bowel disease </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> and COX-2, especially </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> COX-2-1195A→G gene variants AA carriers </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;color:rgb(33,33,33);" xml:lang="en-us">in a Turkish population </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">.
Researches need to focus on their local roles on </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">inflammatory bowel disease </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> pathogenesis </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">with large sample size. </span> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </p> <p> </p> <p> <b> </b> </p> <b> </b>}, number={2}, publisher={Mustafa HASBAHÇECİ}