TY  - JOUR
T1  - Non-alkolik nedenlere bağlı gelişen Wernicke ensefalopatisinde manyetik rezonans görüntüleme bulguları
TT  - Magnetic resonance imaging findings of Wernicke’s encephalopathy in non-alcoholic patients
AU  - Eraslan, Cenk
AU  - Güler, Ayşe
AU  - Kurt, Erman
AU  - Çallı, Cem
AU  - Kitiş, Ömer
PY  - 2019
DA  - June
DO  - 10.19161/etd.418147
JF  - Ege Tıp Dergisi
JO  - EJM
PB  - Ege University
WT  - DergiPark
SN  - 1016-9113
SP  - 115
EP  - 120
VL  - 58
IS  - 2
LA  - tr
AB  - Amaç: Wernickeensefalopatisi (WE) tiamin (vitamin B1) eksikliğine bağlı olarak gelişennöropsikiyatrik bir hastalıktır. Sıklıkla kronik alkolizme bağlı olarakgörülmekle birlikte tiamin alım veya emilim eksikliğine neden olan her türlüdurumda ortaya çıkabilir. Bu çalışmanın amacı tedavi edilmediği takdirde ölümekadar giden ciddi sonuçlar doğurabilen bu hastalığın tanı ve izleminde manyetikrezonans görüntülemenin (MRG) önemini vurgulamaktır.Gereç veYöntem:Çalışmamıza kurumumuzda hospitalize edilen ve non-alkolik nedenlerle WE tanısıalan 10 hasta dahil edildi. Hastaların MRG tetkiklerinde tutulum yerlerininlokalizasyonuna göre tipik ve atipik bulguların varlığı değerlendirildi. Ayrıcaeşlik eden difüzyon kısıtlılığı varlığı araştırıldı.Bulgular: Kraniyal MRG’de tipiktutulum alanları 10 hastada bilateral talamus mediali, 8 hastada bilateralmamiller cisim, 7 hastada periakuaduktal alan/tektal plak olarak tespit edildi.Atipik tutulum alanları ise 5 hastada forniks, 4 hastada serebral korteks, 2hastada putamen, 1 hastada ise serebellum tutulumu şeklinde idi. 8 hastada bubulgulara difüzyon kısıtlılığı eşlik etmekteydi.Sonuç: Sunulan çalışmanın sonuçlarına göre, non-alkolik WE tanılı olgularda MRG’de, alkolik WE tanılı olgularla benzer bulgular gözlenmektedir. Bu hastalarıntanı ve tedavilerinin gecikmemesi amacıyla MR görüntülemenin kullanımınınönemli rol oynadığı sonucuna varılmıştır.
KW  - Wernicke ensefalopatisi
KW  - manyetik rezonans görüntüleme
KW  - tiamin eksikliği.
N2  - Aim: Wernickeencephalopathy (WE) is a neuropsychiatric disease that develops due to thedeficiency of thiamine (vitamin B1). It is often observed due to chronicalcoholism; however it can arise in any condition that causes deficiency in theintake or absorption of thiamine. The aim of this study is to emphasize theimportance of magnetic resonance imaging (MRI) in the diagnosis and follow-up ofthis disease which can even lead to death when it is not treated. Materialsand Methods: Ten patients, who had been hospitalized in our institution anddiagnosed as WE due to non-alcoholic reasons, were included in our study. Inthe MRI examinations of the patients, typical and atypical findings wereevaluated according to the localization of involvement areas. The existence ofaccompanying diffusion restriction was evaluated. Results: Typical involvementareas in cranial MRI were determined as bilateral medial thalamus in 10patients, bilateral mammillary bodies in 8 patients, periaqueductal area/tectalplate in 7 patients. Atypical involvement areas were determined as fornix in 5patients, cerebral cortex in 4 patients, putamen in 2 patients and cerebelluminvolvement in 1 patient. These findings were accompanied by diffusionrestriction in 8 patients. Conclusion: According to theresults of the presented study, cranial MRI has similar findings in alcoholicand non-alcoholic WE patients. We conclude that, the utilization of cranial MRIin these patients has an important role to prevent the latency of the diagnosisand treatment.
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UR  - https://doi.org/10.19161/etd.418147
L1  - https://dergipark.org.tr/en/download/article-file/692625
ER  -