TY  - JOUR
T1  - Yeşil Kimya Ölçümleri: Katalizörlü ve Katalizörsüz Reaksiyon Şartlarında Sentezlenmiş Biginelli Bileşiklerinin Yeşil Kimya Ölçümlerinin Hesaplanması
TT  - Green Chemistry Metrics: Calculation of Green Chemistry Metrics of Biginelli Compounds Synthesized Under the Catalyst and Catalyst-Free Reaction Conditions
AU  - Gülten, Şirin
PY  - 2018
DA  - December
DO  - 10.31590/ejosat.418791
JF  - Avrupa Bilim ve Teknoloji Dergisi
JO  - EJOSAT
PB  - Osman SAĞDIÇ
WT  - DergiPark
SN  - 2148-2683
SP  - 61
EP  - 69
IS  - 14
LA  - tr
AB  - Bu çalışmada, MgBr2 veyaMgCl2·6H2O katalizlenmiş, çözücüsüz ve katalizörsüz, çözücülü (EtOH) reaksiyonşartlarında sentezlenmiş oniki adet Biginelli bileşiğinin atom ekonomisi,çevresel etki faktörü (E-faktör), karbon etkinliği, reaksiyon kütle etkinliğive kütle yoğunluğu gibi yeşil kimya ölçümleri hesaplanmıştır. Tüm yeşil kimyaölçüm sonuçları karşılaştırılmış ve oniki Biginelli bileşiği için en iyi yeşilkimya reaksiyon şartları ve yeşil ölçümler belirlenmiştir.
KW  - Yeşil Kimya Ölçümleri
KW  - Atom Ekonomisi
KW  - Çevresel Etki Faktörü
KW  - Karbon Etkinliği
KW  - Reaksiyon Kütle etkinliği
KW  - Biginelli Reaksiyonu
N2  - In this study, green chemistry metrics such asatom economy, environmental factor (E-factor), carbon efficieny, reaction massefficiency and mass intensity of synthesized twelve Biginelli compounds underMgBr2 or MgCl2·6H2O catalysed, solvent-free and catalyst-free with solvent(EtOH) conditions were calculated. All green chemistry metrics results werecompared and the best green chemistry reaction conditions and green metrics fortwelve Biginelli compounds were determined.
CR  - Biginelli, P. (1891a). Intorno ad uramidi aldeidiche dell’etere acetilacetico. Gazzetta chimica Italiana, 21,  337-340.
CR  - Biginelli, P. (1891b). Intorno ad uramidi aldeidiche dell’etere acetilacetico. Gazzetta chimica Italiana, 21, 455-461.
CR  - Biginelli, P. (1891c). Ueber Aldehyduramide des Acetessigäthers. Berichte der deutschen chemischen Gesellschaft, 24, 1317-1319.
CR  - Biginelli, P. (1891d). Ueber Aldehyduramide des Acetessigäthers. II. Berichte der deutschen chemischen Gesellschaft, 24, 2962-2967.
CR  - Biginelli, P. (1893). Aldehyde-urea derivatives of aceto- and oxaloacetic acids. Gazzetta chimica Italiana, 23, 360-413.
CR  - Atwal K. S., Rovnyak G. C., O'Reilly B. C., Schwartz J. (1989). Substituted 1,4-dihydropyrimidines. 3. Synthesis of selectively functionalized 2-hetero-1,4- dihydropyrimidines. Journal of Organic  Chemistry, 54, 5898-5907.  doi: 10.1021/jo00286a020
CR  - Atwal K.S., Rovnyak G. C., Kimball D., Floyd D. M., Moreland S., Swanson B. N., Gougoutas J. Z., Schwartz J., Smillie K. M., Malley M. F. (1990). Dihydropyrimidine calcium channel blockers. II. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines. Journal of  Medicinal Chemistry, 33, 2629-2635. doi: 10.1021/jm00167a035
CR  - Kappe C. O., Fabian W. M. F., Semones M. A. (1997). Conformational analysis of 4-aryl-dihydropyrimidine calcium channel modulators. A comparison of ab initio, semiempirical and X-Ray crystallographic studies. Tetrahedron, 53, 2803-2816. doi: 10.1016/S0040-4020(97)00022-7
CR  - Rovnyak G. C., Kimball S. D., Beyer B., Cucinotta G., DiMarco J. D., Gougoutas J., Hedberg A., Malley M., McCarthy J. P. (1995). Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators. Journal of  Medicinal Chemistry, 38,119-129. doi: 10.1021/jm00001a017
CR  - Anastas P. T., Warner J. C. (1998). Green Chemistry: Theory and Practice, Oxford University Press: New York, 30.
CR  - Constable, D. J. C., Curzons, A. D., Cunningham V.L. (2002). Metrics to ‘green’ chemistry- which are the best? Green Chemistry, 4,  521-527. doi: 10.1039/b206169b
CR  - Sheldon R. A. (2007). The E Factor: fifteen years on. Green Chemistry, 9, 1273-1283. doi: 10.1039/B713736M
CR  - Sheldon R. A. (2008). E factors, green chemistry and catalysis: an odyssey. Chemical  Communications, 3352-3365. doi: 10.1039/B803584A
CR  - Trost B. M. (1991).  The atom economy-a search for synthetic efficiency. Science, 254, 1471-1477.
CR  - Trost B. M. (1995). Atom Economy-A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way. Angewandte Chemie International Edition in English, 34, 259-281. doi: 10.1002/anie.199502591
CR  - Gülten. S. (2013). Magnesium bromide and magnesium chloride hexahydrate catalyzed one-pot synthesis of dihydropyrimidines via Biginelli reaction under solvent-free conditions. Journal of Heterocyclic Chemistry, 50, 391-395. doi: 10.1002/jhet.980
UR  - https://doi.org/10.31590/ejosat.418791
L1  - https://dergipark.org.tr/en/download/article-file/570106
ER  -