@article{article_42104, title={TNF-a TAYİNİ İÇİN REFLEKTOMETRİK İNTERFERANS SPEKTROSKOPİSİ TEMELLİ SENSÖR GELİŞTİRİLMESİ}, journal={Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering}, volume={11}, pages={141–147}, year={2010}, author={Emir Diltemiz, Sibel and Atılır Özcan, Ayça and Yalçınkaya, Özlem}, keywords={TNF-α, Reflektometrik interferans spektroskopisi, Biyosensör sistemleri}, abstract={<!--[if gte mso 9]> <xml> <w:WordDocument> <w:View>Normal </w:View> <w:Zoom>0 </w:Zoom> <w:HyphenationZone>21 </w:HyphenationZone> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false </w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false </w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false </w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4 </w:BrowserLevel> </w:WordDocument> </xml> <![endif]--> <!--[if gte mso 9]> <xml> <w:LatentStyles DefLockedState="false" LatentStyleCount="156"> </w:LatentStyles> </xml> <![endif]--> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normal Tablo"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <![endif]--> <span style="font-size: 12pt; font-family: TimesNewRomanPS-BoldMT;">In this work, sensor systems based on reflectometric interference spectroscopy has been prepared for selectively recognition and binding of TNF- </span> <span style="font-size: 12pt; font-family: Symbol;"> <span>a </span> </span> <span style="font-size: 12pt; font-family: TimesNewRomanPS-BoldMT;"> biomolecules. For this purpose, carboxymethyldextran coated and reflectometric interference spectroscopy based sensor systems have been activated for binding of suitable orientated antibody, then anti-TNF- </span> <span style="font-size: 12pt; font-family: Symbol;"> <span>a </span> </span> <span style="font-size: 12pt; font-family: TimesNewRomanPS-BoldMT;"> antibody has been bounded on the surface and binding efficiency and binding constants of prepared sensors have been investigated </span>}, number={2}, publisher={Eskisehir Technical University} }