@article{article_421499, title={Prevalence of cagA and babA2 positive Helicobacter pylori strains in dyspeptic patients in Iran}, journal={Journal of Immunology and Clinical Microbiology}, volume={1}, pages={10–13}, year={2016}, DOI={10.5455/jicm.5.20160514}, author={Esmaeillu, Mahsa}, keywords={Helicobacter pylori,babA2,cagA,gastric disorders}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;"> <b> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:Cambria, serif;" xml:lang="en-us">Background: </span> </b> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:Cambria, serif;" xml:lang="en-us"> <i>Helicobacter pylori </i> genome encodes a
large number of virulence and adhesion factors that involved in bacterial
adhesion to host cells and exerts its virulence effect with CagA
secretion.  In this study, we aimed to
examine the relationships between <i>babA2 </i>
and <i>cagA </i> genotype and presence of
gastric disorders in patients from Iran. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;"> <b> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:Cambria, serif;" xml:lang="en-us">Material and Methods: </span> </b> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:Cambria, serif;" xml:lang="en-us">The presence of <i>H.
pylori </i> and selected genes ( <i>cagA </i>and <i>babA2 </i>) were detected by PCR method
from the genomic DNA of 105 patients who had been diagnosed with gastric
disorders like chronic gastritis by endoscopic and histopathologic routes. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;"> <b> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:Cambria, serif;" xml:lang="en-us">Results: </span> </b> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:Cambria, serif;" xml:lang="en-us">
Presence of <i>H. pylori </i> ( <i>glmM gene </i>) was detected in 85 out of 105
(80.9%) patients. According to our results <i>cagA </i>
gene was found in 66 out of 85 (77.6%) patients and <i>babA2 </i> gene was found in 80 out of 85 (94.1%) patient. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;"> <b> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:Cambria, serif;" xml:lang="en-us">Conclusion: </span> </b> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:Cambria, serif;" xml:lang="en-us"> In
conclusion, the <i>cagA </i> and <i>babA2 </i> genotypes might be considered as
useful biomarkers for non-ulcer disease (NUD) patients and gastric disorders in
the geographic region of Iran and the presence of <i>H. pylori </i> strains with double-positive status is high clinical
relevance to <i>H. pylori </i>-associated
diseases. </span> </p> <p> </p>}, number={1}, publisher={Erkan YULA}