@article{article_422255, title={Synthesis of an Antimicrobial Thioanthraquinone Compound to Produce Biodegradable Electrospun Mats for Tissue Engineering Purposes}, journal={Journal of the Turkish Chemical Society Section A: Chemistry}, volume={5}, pages={1119–1134}, year={2018}, DOI={10.18596/jotcsa.422255}, author={Şahin, Yeşim Müge}, keywords={Anthraquinone,synthesis,electrospun mat,biomaterial,biodegradable material,biomaterial}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:150%;"> <span lang="en-gb" style="font-size:10pt;line-height:150%;font-family:Verdana, sans-serif;" xml:lang="en-gb">In the present study
for the first time in the literature, novel S-substituted bioactive
anthraquinone compound were synthesized with a new, easy and less energetic
reaction method (Patent Number: TR2016/19610) from 1-chloro-9,10-dihydrodiagnosisxy-anthraquinone
and butyl-3-mercaptopropionate. The resultant structure present remarkable
biological properties It was purified by column chromatography. All obtained
structures were characterized with spectroscopic methods (NMR, MS, FT-IR, UV
etc). Antimicrobial properties of bioactive compound were determined as well.
The resultant thioanthraquinone compound has been synthesized for the first
time in the literature and its applications as a biomaterial were discussed in
the present study. <b> </b> </span> </p> <p> <b> </b> </p> <b> </b> <p class="Abstract" style="text-indent:0cm;line-height:150%;"> <span lang="en-gb" style="font-size:10pt;line-height:150%;font-family:Verdana, sans-serif;" xml:lang="en-gb">Subsequently, biodegradable electrospun mats were
produced via electrospinning method for their usage in treatment as a
biomaterial. Structural (FTIR), morphological (FEG-SEM) biological
(antimicrobial and in-vitro tests) and mechanical (tensile testing) characterizations
were conducted for these nanobiomaterials. Presenting an advantage of the novel
antimicrobial compound, the produced electrospun nanobiocomposites exhibited
remarkable biological, mechanical properties. With a purposeful compound
synthesis and a subsequent nanobiocomposite production, the obtained
electrospun mats are good canditates for biomaterials for tissue engineering
purposes and wound healing materials.  </span> </p> <p> </p>}, number={3}, publisher={Turkish Chemical Society}