@article{article_423605, title={Fibromyalgia syndrome in chronic hemodialysis patients is associated with depression, hypoalbuminemia and inflammation}, journal={The European Research Journal}, volume={5}, pages={729–733}, year={2019}, DOI={10.18621/eurj.423605}, author={Gürlek Demirci, Bahar and Tutal, Emre and Erkmen, Mehtap and Erdoğan, Elçin and Sezer, Siren}, keywords={Fibromyalgia,hemodialysis,depression}, abstract={<p> <b> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">Objectives: </span> </b> <span lang="en-us" style="margin:0px;color:rgb(0,0,0);line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">Fibromyalgia syndrome (FMS) is an
entity that presents with wide-spread chronic pain in musculoskeletal system </span> <span lang="en-us" style="margin:0px;color:rgb(0,0,0);line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">, disturbed sleep, reduced mental functioning and depressed mood </span> <span lang="en-us" style="margin:0px;color:rgb(0,0,0);line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">. We aimed to
determine the incidence of FMS in our hemodialysis patients and to evaluate the
association between FMS, depression and inflammation in patients ongoing
hemodialysis. </span> </p> <p> <b> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">Methods: </span> </b> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">Among </span> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:12pt;" xml:lang="en-us"> <span style="font-size:18px;">169 patients, 140
patients </span> <span style="margin:0px;color:rgb(0,0,0);font-size:18px;">were enrolled into our study. </span> <span style="font-size:18px;">Twenty-nine
patients were excluded according to exclusion criteria. </span> <span style="margin:0px;color:rgb(0,0,0);font-size:18px;">Demographic characteristics including age, sex, body mass index,
duration of dialysis, the etiology of end stage renal disease, the dialysis
adequacy (Kt/V) were also recorded. All patients were evaluated through 2010
ACR preliminary diagnostic criteria including </span> </span> <span lang="en-us" style="margin:0px;color:rgb(0,0,0);line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">widespread pain index (WPI)
and total symptom severity. </span> <span lang="en-us" style="margin:0px;color:rgb(0,0,0);line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">All subjects completed Beck
depression inventory (BDI) to determine psychological status. </span> </p> <p> <b> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">Results: </span> </b> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">Among 140 hemodialysis
patients, 76 (54.2%) patients presented chronic widespread pain and 20 patients
(14.2%) met the 2010 ACR criteria for FMS. </span> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:12pt;" xml:lang="en-us"> <span style="font-size:18px;">Patients were divided
into FMS (n = 20; 14.2%) and non-FMS (n = 120; 85.8%) groups. FMS group had
significantly higher serum C-reactive protein levels and lower serum albumin
levels when compared to non-FMS group. BDI (31.4 ± 1.4 vs 14.8 ± 0.6, </span> <i> <span style="font-size:18px;">p </span> </i> <span style="font-size:18px;"> < 0.005), WPI (11.2 ± 0.7 vs 2.8±
0.2, </span> <i> <span style="font-size:18px;">p </span> </i> <span style="font-size:18px;"> = 0.002) and </span> </span> <span lang="en-us" style="margin:0px;color:rgb(0,0,0);line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">symptom severity </span> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:12pt;" xml:lang="en-us"> <span style="font-size:18px;"> (7.3 ± 0.3 vs 3.7 ± 0.1, </span> <i> <span style="font-size:18px;">p </span> </i> <span style="font-size:18px;"> < 0.005) scores were
significantly higher in FMS group. </span> </span> </p> <p> <b> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">Conclusions: </span> </b> <span lang="en-us" style="margin:0px;line-height:150%;font-family:’Times New Roman’, serif;font-size:18px;" xml:lang="en-us">The FMS itself and the
related symptoms were correlated with depression in maintenance hemodialysis
patients. Besides, inflammation and perhaps malnutrition-inflammation sydrome
may trigger FMS in this population. </span> </p> <p> <b> </b> <i> </i> <u> </u> <sub> </sub> <sup> </sup> <strike> </strike> <font size="3"> </font> <font face="Times New Roman"> </font> <br /> </p> <p style="margin:0px 0px 10.66px;line-height:normal;"> <b> <font face="Calibri" size="3">  </font> </b> </p> <p> <b> </b> <i> </i> <u> </u> <sub> </sub> <sup> </sup> <strike> </strike> <font face="Calibri"> </font> <font size="3"> </font> <font face="Times New Roman"> </font> <br /> </p>}, number={5}, publisher={Prusa Medical Publishing}