TY  - JOUR
T1  - Cholinesterase, α-Glucosidase, α-Amylase, and Tyrosinase Inhibitory Effects and Antioxidant Activity of Veronica officinalis Extracts
TT  - Cholinesterase, α-Glucosidase, α-Amylase, and Tyrosinase Inhibitory Effects and Antioxidant Activity of Veronica officinalis Extracts
AU  - Uçar, Esra
AU  - Eruygur, Nuraniye
PY  - 2018
DA  - October
DO  - 10.19159/tutad.425732
JF  - Türkiye Tarımsal Araştırmalar Dergisi
JO  - TÜTAD
PB  - Siirt University
WT  - DergiPark
SN  - 2148-2306
SP  - 253
EP  - 259
VL  - 5
IS  - 3
LA  - en
AB  - In this study, inhibition ability of Veronica officinalis extracts againstAlzheimer’s disease-related enzymesacetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), diabetesmellitus related enzymes α-glucosidase and α-amylase and antioxidant of Veronicaofficinalis were investigated. To the best of our knowledge, there are noprevious studies on the enzyme inhibition activities of the V. officinalisextracts. For this aim, V. officinalisextracted with methanol and water by maceration method and their antioxidantactivities were evaluated by DPPH (2,2-Diphenyl-1-picrylhydrazyl), ABTS [2,2′-Azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid)] radical scavengingassays, total phenol, total flavonoid content, iron chelating and ferricreducing power assays. The enzyme inhibition activity was performed with96-well plate method. According to the obtained results; the plant extractshave good antioxidant effects. In the same time, the water extract havestronger inhibition activity against AChE, BuChE and α-glucosidase, α-amylase,and tyrosinase than methanol extract. The experimental findings indicated thatthe water extract exerted the higher α-glucosidase, α-amylase and tyrosinase(82.07 ± 2.91, 63.61 ± 3.93 and 47.47 ± 0.53 at 2 mg mL-1,respectively) inhibition than reference drugs. The obtained results demonstratethat this plant has a significant potential for improving pharmaceuticalformulations.
KW  - Antioxidant
KW  - alzheimer’s
KW  - diabetes
KW  - tyrosinase
KW  - Veronica officinalis
N2  - In this study, inhibition ability of Veronica officinalis extracts againstAlzheimer’s disease-related enzymesacetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), diabetesmellitus related enzymes α-glucosidase and α-amylase and antioxidant of Veronicaofficinalis were investigated. To the best of our knowledge, there are noprevious studies on the enzyme inhibition activities of the V. officinalisextracts. For this aim, V. officinalisextracted with methanol and water by maceration method and their antioxidantactivities were evaluated by DPPH (2,2-Diphenyl-1-picrylhydrazyl), ABTS [2,2′-Azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid)] radical scavengingassays, total phenol, total flavonoid content, iron chelating and ferricreducing power assays. The enzyme inhibition activity was performed with96-well plate method. According to the obtained results; the plant extractshave good antioxidant effects. In the same time, the water extract havestronger inhibition activity against AChE, BuChE and α-glucosidase, α-amylase,and tyrosinase than methanol extract. The experimental findings indicated thatthe water extract exerted the higher α-glucosidase, α-amylase and tyrosinase(82.07 ± 2.91, 63.61 ± 3.93 and 47.47 ± 0.53 at 2 mg mL-1,respectively) inhibition than reference drugs. The obtained results demonstratethat this plant has a significant potential for improving pharmaceuticalformulations.
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UR  - https://doi.org/10.19159/tutad.425732
L1  - https://dergipark.org.tr/en/download/article-file/556966
ER  -