@article{article_430145, title={Correlation between gross morphology of the human placenta and birth weight in normotensive and pre-eclamptic pregnancies in Northwest Ethiopia}, journal={Anatomy}, volume={12}, pages={27–32}, year={2018}, url={https://izlik.org/JA59GJ85AC}, author={Tiruneh, Shibabaw Tedla}, keywords={birth weight; morphology; placenta; pre-eclampsia}, abstract={<p> <span style="font-size:12.6px;">Objectives: The objective of this study was to investigate correlation of gross morphology of human placenta with birth </span> </p> <p> <span style="font-size:12.6px;">weight in normotensive and pre-eclamptic pregnancies obtained from Bahir Dar, Northwest Ethiopia. </span> </p> <p> <span style="font-size:12.6px;">Methods: Institutional based comparative cross-sectional study was carried out on 200 term placentas (37 to 42 weeks of gestation) </span> </p> <p> <span style="font-size:12.6px;">between October and January 2015. 150 placentas from normotensive and 50 from pre-eclamptic pregnancies were collected </span> </p> <p> <span style="font-size:12.6px;">and examined for weight, diameter, thickness and number of cotyledon. Birth weight and placental-fetal weight ratio also </span> </p> <p> <span style="font-size:12.6px;">measured. </span> </p> <p> <span style="font-size:12.6px;">Results: The mean birth weight in pre-eclamptic pregnancies (2.6 kg) was significantly (p=0.0001) reduced as compared to birth </span> </p> <p> <span style="font-size:12.6px;">weight (3.1 kg) in normotensive pregnancies. However, placental-fetal weight ratio had no significant (p=0.658) difference </span> </p> <p> <span style="font-size:12.6px;">between normotensive (6.34:1) and pre-eclamptic (6.41:1) groups. Birth weight was correlated with placental weight (r=0.572), </span> </p> <p> <span style="font-size:12.6px;">diameter (r=0.583), thickness (r=0.192) and number of cotyledons (r=0.647) in the pre-eclamptic group. Birth weight was also </span> </p> <p> <span style="font-size:12.6px;">correlated with placental weight (r=0.572), diameter (r=0.583), and number of cotyledons (r=0.647) in the normotensive group. </span> </p> <p> <span style="font-size:12.6px;">However, no correlation was found between placental thickness (r=0.192) and birth weight in the normotensive group. </span> </p> <p> <span style="font-size:12.6px;">Conclusion: Birth weight was significantly reduced in pre-eclamptic pregnancies as compared to normotensive pregnancies. </span> </p> <p> <span style="font-size:12.6px;">Morphology of placenta such as weight, diameter and number of cotyledons were correlated with birth weight in both </span> </p> <p> <span style="font-size:12.6px;">groups, but placental thickness was only correlated with birth weight in pre-eclampsia, but not in normotensive group. </span> </p> <p> <span style="font-size:12.6px;">Placental-fetal weight ratio had not significant difference between the groups. Examination of placental morphology prenatally </span> </p> <p> <span style="font-size:12.6px;">using ultrasound and observation immediately after delivery is important for better management of this and subsequent </span> </p> <p> <span style="font-size:12.6px;">pregnancies. </span> </p>}, number={1}