TY  - JOUR
T1  - Helicobacter pylori ENFEKSİYONUNDA PROBİYOTİKLERİN ROLÜ
TT  - ROLE OF PROBIOTICS IN Helicobacter pylori INFECTION
AU  - Akdeniz, Vildan
AU  - Akalın, A. Sibel
AU  - Özer, Elif
PY  - 2018
DA  - November
DO  - 10.15237/gida.GD18062
JF  - Gıda
JO  - GIDA
PB  - The Association of Food Technology
WT  - DergiPark
SN  - 1300-3070
SP  - 943
EP  - 956
VL  - 43
IS  - 6
LA  - tr
AB  - Dünya Sağlık Örgütü tarafından kanserojen gruptasınıflandırılan Helicobacter pylori enfeksiyonu yüksek tekrarlanmasıklığı ile hem gelişmekte olan hem de gelişmiş ülkelerde görülen önemli birhalk sağlığı sorunudur. H. pylori'nin mide mukozasında kolonize olarakkronik gastritin ana nedenini oluşturduğu bilinmektedir. Mide mikrobiyotası H.pylori’nin sebep olduğu hastalıkların oluşmasında ve gelişmesinde önemlibir rol oynamaktadır. Beslenme düzenindeki değişimlerle gastrik mukozadaki H.pylori yoğunluğunda azalma sağlanması, H. pylori ile ilişkili peptikülser, kronik gastrit, mide adenokarsinoması, mukoza ile ilişkili lenfoid dokulenfoması ve duodenal ülser hastalığı gibi hastalıkların ortaya çıkma riskiniazaltmaya yardımcı olacaktır. H. pylori enfeksiyonunda antibiyotiktedavisi uygulanmakta, fakat bu süreçte antibiyotik direnci ve antibiyotik tedavisininyan etkileri görülebilmektedir. Yapılan çalışmalar bağırsak mikrobiyotasıüzerinde olumlu etkiye sahip olan probiyotiklerin; H. pylori enfeksiyonutedavisinde eradikasyon oranını arttırdığını, hasta klinik belirtileriniiyileştirdiğini ve tedaviye bağlı antibiyotik ile ilişkili yan etkileriazaltarak hasta uyumunu arttırdığını belirtmektedir.
KW  - Helicobacter pylori
KW  - probiyotik
KW  - antibiyotik tedavisi
N2  - Helicobacter pylori infection which is recognized as carcinogen by WHO is amajor public health problem in both developing and developed countries withhigh prevalence. It is well known that H. pylori causes mainly tochronic gastritis colonising in the gastric mucosa. Gastric microbiota isimportant in the occurrence and development of diseases caused by H. pylori.Nutritional modification providing a reduction in the population of H.pylori at the gastric mucosa will help to decrease the risk of H. pylori-associateddiseases including peptic ulcer, chronic gastritis, gastric adenocarcinoma,mucosa associated lymphoid tissue lymphoma and duodenal ulcer disease.Antibiotic therapy is applied in this infection, but meanwhile it’s sideeffects and antibiotic resistance be seen. Studies indicate that probioticswhich have positive effects on intestinal microbiota increase eradication ratesof H. pylori, improve patient clinical symptoms and improve patientcompliance by reducing side effects associated with antibiotic treatment.
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UR  - https://doi.org/10.15237/gida.GD18062
L1  - https://dergipark.org.tr/en/download/article-file/580590
ER  -