@article{article_435112, title={Protective Effect of N-Acetylcysteine on Testicular Oxidative Damage, Spermatological Parameters and DNA Damage in Glyphosate-Based Herbicide-Exposed Rats}, journal={Kocatepe Veterinary Journal}, volume={11}, pages={292–300}, year={2018}, DOI={10.30607/kvj.435112}, author={Avdatek, Fatih and Türkmen, Ruhi and Demirel, Hasan Hüseyin and Birdane, Yavuz Osman}, keywords={N-acetylcysteine,Glyphosate,Rat sperm,DNA damage}, abstract={<p class="MsoNormal" style="text-align:justify;"> <span lang="en-us" style="font-size:10pt;font-family:Garamond, serif;" xml:lang="en-us">The aim of this
study was to examine the protective effect of N-acetylcysteine (NAC) on
testicular oxidative damage, spermatological parameters and DNA damage caused
by Glyphosate (GLF) in rats. </span> <span style="font-size:10pt;font-family:Garamond, serif;">In
total, twenty-eight </span> <span lang="en-us" style="font-size:10pt;font-family:Garamond, serif;" xml:lang="en-us"> Wistar male
rats were evaluated by being separated into four groups in an equal way. Rats
in group I, which represented the control
group, were fed normal diet without GLF
or NAC, group II received normal feed containing
160 mg/kg/daily NAC, group III received normal feed containing 375 mg/kg/daily
GLF, and group IV received normal feed containing 160 mg/kg/daily NAC + 375
mg/kg/daily GLF. GLF administration decreased sperm motility, abnormal
sperm rate, sperm plasma membrane integrity,
glutathione level and superoxide dismutase in the rats’ testicular tissue. On
the other hand, high malondialdehyde level and DNA damage were detected in the
group administered with GLF. Besides, in histopathological terms, a decrease in
sperm concentration and degeneration of sertoli cells were determined in the
testicular tissue. NAC and NAC+GLF administration reversed lipid peroxidation
and DNA damage induced by GLF, the activity
of antioxidant enzymes and cell integrity in rats’ testis. The above-mentioned
findings indicate that NAC reduces lipid peroxidation caused by GLF, improves
the antioxidant defense mechanism and regenerates tissue damage in rats’
testis. </span> </p> <p> </p> <p> </p>}, number={3}, publisher={Afyon Kocatepe University}