TY  - JOUR
TT  - Antinociceptive activity of aqueous extract of Lepidium Sativum L. in mice
AU  - Özdemir, Hülya
AU  - Yaren, Biljana
AU  - Oto, Gökhan
PY  - 2015
DA  - December
JF  - EASTERN JOURNAL OF MEDICINE
PB  - Van Yuzuncu Yıl University
WT  - DergiPark
SN  - 1301-0883
SP  - 131
EP  - 135
VL  - 20
IS  - 3
N2  - Antinociceptive activity of aqueous extract of Lepidium Sativum L. in miceAbstractPurpose: In the present study the aqueous extract of Lepidium Sativum L. (family: Brassicaceae) was investigated for possible antinociceptive effect in Swiss - albino male mice.Material and Methods: In this experiment three groups of male mice were used (n=6). Two models were used to study the effects of the extracts on nociception, acetic acid-induced writhing test and hot plate test in mice. Lepidium Sativum extract was administered in the dose of 20 mg/kg orally 30 minutes prior to pain induction.Results: The aqueous extract showed significant (p < 0.05) analgesic activity evidenced by increase in the reaction time by hot plate method and significant (p < 0.05) reduction in acetic acid - induced writhings in mice with a maximum effect of 27.00 % reduction. These effects were compared with the control and standard drug, diclofenac sodium (50 mg/kg, p.o).Conclusion: The results indicate that aqueous extract of Lepidium Sativum possesses a significant antinociceptive activity in central and peripheral pain models in mice and therefore, it can be used as supplemental therapy in acute or chronic pain conditions.Keywords: Antinociception, aqueous extract, Lepidium Sativum L., Hot plate, Writhing test.
UR  - https://dergipark.org.tr/en/pub/ejm/issue//438013
L1  - https://dergipark.org.tr/en/download/article-file/496280
ER  -