@article{article_440016, title={Relationship between atherosclerosis risks and lipoprotein-dependent phospholipase a2 activity in type 2 diabetic patients}, journal={Journal of Surgery and Medicine}, volume={3}, pages={31–35}, year={2019}, DOI={10.28982/josam.440016}, author={Ayan, Durmuş and Çaycı Sivri, Ayşe Banu and Yüksel, Seher and Yetkin, İlhan and Özdemir, Hakan}, keywords={Lp-PLA2,Atherosclerosis,Diabetes,Statin therapy,Intima-media thickness}, abstract={<p>Aim: Atherosclerosis is the most common macro-complication of diabetes and the most common cause of coronary artery disease. We aimed to investigate the relationship between the risk of atherosclerosis and lipoprotein-dependent phospholipase A2 activity in patients with type 2 diabetes. </p> <p>Methods: The study was enrolled on 48 subjects: Group I: control group consisting of 20 healthy participants. Group II: 28 patients of type 2 diabetes mellitus before statin (rosuvastatin 10 mg/day) therapy. Group III: 28 patients of type 2 diabetes mellitus after statin (rosuvastatin 10 mg/day) therapy. Lp-PLA2 activity was measured with immuno- turbidimetric method (plac test kit), HDL-C (High-Density Lipoprotein Cholesterol), LDL-C (Low-Density Lipoprotein Cholesterol), triglyceride, cholesterol and fasting blood glucose (FBG), levels were measured by spectrophotometric method using autoanalyzer (Architect C16000). LDL-C levels were measured by an assay for the direct quantification of LDL-C. Carotid intima-media thickness (IMT) was measured by B-mode ultrasonography method.  </p> <p>Results: Serum Lp-PLA2 activity, serum LDL-C, triglyceride, cholesterol levels and IMT values of Group II (before 10 mg/gün rosuvastatin therapy ) and Group III (after rosuvastatin therapy) patients were statistically significant higher than Group I (control group) (p<0.01) Serum Lp-PLA2 activity, serum LDL-C, triglyceride, cholesterol levels and IMT values of Group II patients were statistically significant higher than Group III patients (p<0.01) and HDL-C levels only were lower than Group III (after 10 mg/gün rosuvastatin therapy) but It was not statistically significant (p=0.198). </p> <p>Conclusion: According to our results, Increased Lp-PLA2 activity is associated with risk of atherosclerosis in diabetic patients and plays an important role in the progression of atherosclerosis. </p> <div> <br /> </div>}, number={1}, publisher={Selçuk BAŞAK}