@article{article_443557, title={Thiol/disulphide homeostasis in Helicobacter pylori infected patients}, journal={The European Research Journal}, volume={5}, pages={948–956}, year={2019}, DOI={10.18621/eurj.443557}, author={Baykan, Ahmed Ramiz and Biçer, Cemile and Gerçeker, Emre and Erel, Özcan and Cerrah, Serkan and Albayrak, Bülent and Utlu, Mustafa and Kargılı, Ayşe}, keywords={Helicobacter pylori,thiol,oxidative stress}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us" lang="en-us">Objectives: </span> </b> <b> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us" lang="en-us"> </span> </b> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb"> <span style="font-size:18px;">The aim of the
study was to evaluate the oxidative stress level in patients, diagnosed with </span> <i> <span style="font-size:18px;">Helicobacter pylori </span> </i> <span style="font-size:18px;">infection, using a
novel marker (thiol/ </span> </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;">disulphide </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb"> <span style="font-size:18px;"> homeostasis) and to compare the level in infected
individuals with that in healthy volunteers. </span> </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us" lang="en-us">Methods: </span> </b> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us" lang="en-us"> </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">A total of </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">60 patients diagnosed with gastritis, erosive gastritis </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">or </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb"> ulcer </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">by </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb"> endoscopy were </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">included and biopsied.
The </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">30 patients </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">diagnosed </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">with </span> <i> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">H. </span> </i> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb"> <span style="font-size:18px;"> </span> <i> <span style="font-size:18px;">pylori </span> </i> <span style="font-size:18px;"> </span> </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">and </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">30 healthy individuals were enrolled. </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb"> Medical </span> <font face="Times New Roman, serif"> <font style="font-size:12pt;" size="3"> <span xml:lang="en-us" lang="en-us"> <span style="background:#ffffff;">histories, physical examination results, body mass index (BMI), hemogram, </span> </span> </font> </font> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating
hormone (TSH), urea, creatinin, aspartate aminotransferase (AST), alanine
aminotransferase (ALT), albumin, total cholesterol, </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">triglycerides </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">, high density lipoprotein (HDL), low density lipoprotein) LDL and  </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb"> </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">thiol/disulphide levels </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">obtained </span> <span style="font-size:18px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb" lang="en-gb">in the study groups </span> <span style="}, number={6}, publisher={Prusa Medical Publishing}