TY  - JOUR
T1  - A One-center Study of Sixteen Patients with Pregnancy-associated Breast Cancer: Clinicopathological Characteristics and Survival
TT  - Gebelikle İlişkili Meme Kanserli 16 Hastaya Dair Tek Merkez Çalışması: Klinikopatolojik Özellikler ve Sağkalım
AU  - Bademler, Süleyman
AU  - Sarı, Murat
PY  - 2018
DA  - September
Y2  - 2018
DO  - 10.21673/anadoluklin.446910
JF  - Anatolian Clinic the Journal of Medical Sciences
JO  - Anatolian Clin
PB  - Hayat Sağlık ve Sosyal Hizmetler Vakfı
WT  - DergiPark
SN  - 2149-5254
SP  - 137
EP  - 142
VL  - 23
IS  - 3
LA  - en
AB  - Aim: Cancer treatment is of special importance during pregnancy, concerning the health of both mother and baby. Treatment of pregnancy-associated breast cancer (PABC) has become even moreimportant today because women tend to delay pregnancy to later ages and because of women who desire to conceive while under treatment for breast cancer. This retrospective study is aimed at investigatingthe clinical, radiological and histopathological characteristics and PABC treatment outcomes of patients who had long-term follow-up.Materials and Methods: Sixteen women diagnosed with PABC were included in this study. We evaluated the clinicopathological characteristics, gestational history, and survival outcomes of the patientswho had been treated and followed up for breast cancer during pregnancy and the first postnatal year at Istanbul University Institute of Oncology in 2010–2017.Results: The median patient age was 32 (21–41) years. The median gestational week of diagnosis in pregnant patients was 26 (11–35) weeks while the mean time elapsed after delivery until diagnosis inpostpartum patients was 9.3 (±3.6) months. The median follow-up time was 47.5 (5–99) months. The mean disease-free survival (DFS) and overall survival (OS) were calculated because the median DFSand OS could not be computed. The mean OS and DFS values were 87.8±7.3 and 77.6±8.5 months,respectively.Discussion and Conclusion: Breast cancer in pregnancy is a special health condition that should be treated and followed up by a multidisciplinary team. Primary surgical intervention should not bedelayed. While chemotherapy could be administered safely in the first and second trimesters, radiotherapy and targeted and endocrine treatments should be postponed until after delivery. Reportingand long-term follow-up of cases of pregnancy and cancer concurrence is essential for increasing the relevant knowledge.
KW  - pregnancy
KW  - breast cancer
KW  - diagnosis
KW  - survival
N2  - Amaç: Gebelikte kanser tedavisi hem anne hem de bebek sağlığı açısından özel bir öneme sahiptir. Günümüzdekadınların gebeliği ileri yaşlara ertelemesi ve meme kanseri tedavisi almakta olan kadınlarıngebelik isteği nedeniyle GİMK tedavisi giderek önem kazanmaktadır. Bu retrospektif çalışma ile uzunsüreli izlemi olan vakaların klinik, radyolojik ve histopatolojik özelliklerini ve GİMK tedavisi sonuçlarınıincelemek amaçlanmıştır.Gereç ve Yöntemler: Bu çalışmaya GİMK tanısı almış olan 16 kadın hasta dahil edilmiştir. 2010–2017döneminde İstanbul Üniversitesi Onkoloji Enstitüsünde gebelik sırasında veya postnatal birinci yıldameme kanseri tanısıyla tedavi ve takip edilen hastaların klinikopatolojik özellikleri, gestasyonel öykülerive sağkalım sonuçları değerlendirilmiştir.Bulgular: Medyan hasta yaşı 32 (21–41) yıldı. Gebe hastaların tanı anındaki medyan gebelik haftası26 (11–35) hafta iken postpartum hastalarda doğumdan sonra meme kanseri tanısına kadar geçenortalama süre 9,3 (±3,6) ay idi. Medyan takip süresi 47,5 (5–99) aydı. Medyan genel sağkalım (GS) vehastalıksız sağkalım (HS) değerlerine ulaşılamadığı için ortalama GS ve HS hesaplandı. Ortalama GSve HS değerleri sırasıyla 87,8±7,3 ve 77,6±8,5 ay idi.Tartışma ve Sonuç: Gebelikte meme kanseri takip ve tedavisi multidisipliner bir ekip tarafından yapılmasıgereken özel bir sağlık sorunudur. Primer cerrahi müdahale geciktirilmemelidir. Kemoterapiikinci ve üçüncü trimesterde güvenle uygulanabilirken radyoterapi, hedefe yönelik tedaviler ve endokrintedavileri doğum sonrasına ertelenmelidir. Gebelik ve kanser birlikteliği vakalarının bildirilmesi ve uzunsüreli takibi ilgili bilgi birikiminin artması bakımından çok önemlidir
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UR  - https://doi.org/10.21673/anadoluklin.446910
L1  - https://dergipark.org.tr/en/download/article-file/555514
ER  -