@article{article_448922, title={Genotyping and analysis of rs3771150 polymorphism to investigate an association with bronchopulmonary dysplasia incidence in Turkish population}, journal={İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi}, volume={4}, pages={16–21}, year={2018}, author={Akat, Ayberk and Yılmaz Semerci, Seda and Uğurel, Osman Mutluhan and Erdemir, Ayşegül and Çetinkaya, Merih and Turgut-balık, Dilek}, keywords={Bronchopulmonary dysplasia,multiplex polymerase chain reaction,single nucleotide polymorphism,SNP genotyping}, abstract={<p>Objectives: rs3771150 polymorphism on IL-18RAP was chosen to be investigated in terms of determining a relationship with BPD incidence seen in preterm infants born in Turkey.  </p> <p>Materials and Method: Allele and genotype frequencies of this polymorphism was analyzed from genotyping results obtained by multiplex reactions and MALDI-TOF mass spectrometry method. In addition, clinical and demographic data obtained from the patients were also inquired in this study to determine any relationship with BPD incidence.  </p> <p>Results: GG genotype has been determined as the wild type genotype of rs3771150 polymorphism for the Turkish population (n=49 in control group, n=46 in BPD group). When other genotypes (AG and AA) were analyzed no significant relationship was found with BPD incidence (p>0.05). </p> <p>Conclusion: No significant relationship could be determined between rs3771150 polymorphism and BPD incidence in 192 preterm Turkish infants. </p>}, number={1}, publisher={Demiroglu Bilim University}