TY  - JOUR
T1  - Determination of Methimazole in Tablets Using Spectrophotometric Methods
TT  - Spektrofotometrik Yöntemlerle Tabletlerde Metimazol Tayini
AU  - Dermiş, Saadet
AU  - Beyaztaş, Sinan
AU  - Ertekin, Zehra Ceren
AU  - Dinç, Erdal
PY  - 2019
DA  - January
DO  - 10.29130/dubited.449055
JF  - Duzce University Journal of Science and Technology
JO  - DÜBİTED
PB  - Duzce University
WT  - DergiPark
SN  - 2148-2446
SP  - 904
EP  - 910
VL  - 7
IS  - 1
LA  - en
AB  - This study describes the spectrophotometric quantification of methimazole in tablets using zero-order absorptionspectrophotometry and first derivative spectrophotometry methods. In preliminary experiments, linearity rangewas found between 2.0-24.0 µg/mL in zero-order spectrophotometry and first-order derivativespectrophotometry. Calibration curves were obtained by measurements of the zero-order absorbances and theirfirst derivative values at 260.0 and 269.0 nm for the zero-order spectrophotometry and first derivativespectrophotometry, respectively. The recovery and relative standard deviations were calculated as 103.3 % and2.18 % for UV absorption spectrophotometry and 98.0% and 0.64% for first derivative spectrophotometry,respectively. The proposed techniques were used for the analysis of tablets preparations. The methods proposedin this study were verified by analyzing validation test samples containing methimazole. Determination resultsshowed that the applied methods were found to suitable for the quantitation of the related drug.
KW  - Methimazole
KW  - UV-VIS Spectrophotometry
KW  - Tablet
N2  - Bu çalışma doğrudan absorbans ölçüm ve türev spektrofotometrik yöntemlerini kullanarak tabletlerdekimethimazolün spektrofotometrik miktar tayinini açıklamaktadır. Yapılan ön çalışmalarda sıfırıncı derece vebirinci türev spektrofotometri yöntemlerinde doğrusal çalışma aralığı 2,0-24,0 µg/mL olarak bulunmuştur.Sıfırıncı derece spektrofometri yönteminde 260,0 nm, birinci derece türev spektrofotometri yönteminde ise 269,0nm dalga boylarında ölçümler yapılarak kalibrasyon eğrileri elde edilmiştir. Geri kazanım ve bağıl standartsapma değerleri; doğrudan absorbans ölçüm yöntemi için % 103,3 ve % 2,18 ve birinci derece türevspektrofotometri için % 98,0 ve % 0,64 olarak bulunmuştur. Daha sonra önerilen teknikler tablet preparatlarınınanalizi için uygulanmıştır. Bu çalışmada metodların uygulanabilirliği, methimazol içeren test örneklerininvalidasyon çalışmalarıyla doğrulanmıştır. Analiz sonuçları, ilacın miktar tayini için ilgili metodlarınuygulanabilir olduğunu göstermektedir.
CR  - [1] M. Aletrari, P. Kanari, D. Partassides and E. Loizou, "Study of the British Pharmacopeia
method on methimazole (thiamazole) content in carbimazole tablets," Journal of Pharmaceutical and
Biomedical Analysis, vol. 16, no. 5, pp. 785-792, 1998.
CR  - [2] H. B. Burch and D. S. Cooper, "Management of Graves disease: a review," JAMA, vol. 314,
no. 23, pp. 2544-2554, 2015.
CR  - [3] P. Abraham, A. Avenell, C. M. Park, W. A. Watson and J. S. Bevan. "A systematic review of
drug therapy for Graves’ hyperthyroidism," European Journal of Endocrinology, vol. 153, no. 4, pp.
489-498, 2005.
CR  - [4] A. Fumarola, A. Di Fiore, M. Dainelli, G. Grani and A. Calvanese. "Medical treatment of
hyperthyroidism: state of the art," Experimental and Clinical Endocrinology & Diabetes, vol. 118, no.
10, pp. 678, 2010.
CR  - [5] C. Donga, C. Y. Zhangb, L. Guoa and Q. Lia, "Spectrophotometric determination of
methimazole in pharmaceutical, serum and urine samples by reaction with potassium ferricyanide-Fe
(III)," Journal of Analytical Chemistry, vol. 65, no. 7, pp. 707-712, 2010.
CR  - [6] C. Sanchez-Pedreno, M. I. Albero, M. S. Garcia and V. Rodenas, "Flow-injection
spectrophotometric determination of carbimazole and methimazole," Analytica Chimica Acta, vol.
308, no. 1-3, pp. 457-461, 1995.
CR  - [7] M. Skowron and W. Ciesielski, "Spectrophotometric determination of methimazole, Dpenicillamine, captopril, and disulfiram in pure form and drug formulations," Journal of Analytical Chemistry, vol. 66, no. 8, pp. 714, 2011.
CR  - [8] M. Aletrari, P. Kanari, D. Partassides and E. Loizou, "Study of the British Pharmacopeia
method on methimazole (thiamazole) content in carbimazole tablets," Journal of Pharmaceutical and
Biomedical Analysis, 16, no. 5, pp. 785-792, 1998.
CR  - [9] N. A. M. Germán, F. A. Bertolino, E. Salinas and J. Raba, "Screen-printed enzymatic
biosensor modified with carbon nanotube for the methimazole determination in pharmaceuticals
formulations," Sensors and Actuators B: Chemical, vol. 133, no. 1 pp. 256-262, 2008.
CR  - [10] M. Aslanoglu and N. Peker, "Potentiometric and voltammetric determination of
methimazole," Journal of Pharmaceutical and Biomedical Analysis, vol. 33, no. 5, pp. 1143-1147,
2003.
CR  - [11] B.,Yilmaz and F. B. Nisanci, "Electrochemical study of methimazole and its direct
determination in pharmaceutical preparations and human serum by square wave and differential pulse
voltammetry," Journal of Pharmaceutical Research and Reviews, vol. 1 no. 5, pp. 1-13, 2017.
CR  - [12] R. Zakrzewski, "Determination of methimazole in pharmaceutical preparations using an HPLC
method coupled with an iodine-azide post-column reaction," Journal of Liquid Chromatography &
Related Technologies, vol. 32, no. 3, pp. 383-398, 2008.
CR  - [13] A. Meulemans, C. Manuel, C. Ferriere and M. Valpillat, "Determination of Methimazole in
Plasma by High Performance Liquid Chromatography," Journal of Liquid Chromatography, vol. 3,
no. 2, pp. 287-298, 1980.
CR  - [14] K. Kuśmierek and E. Bald, "Determination of methimazole in urine by liquid
chromatography," Talanta, vol.71, no. 5, pp. 2121-2125, 2007.
CR  - [15] M. S. Chernov’yants, E. V. Khokhlov and A. O. Dolinkin, "Electrophoretic determination of
1-methyl-2-mercaptoimidazole in the pharmaceutical preparation mercazolyl," Journal of Analytical
Chemistry, vol. 62, no. 3, pp. 263-265, 2007.
UR  - https://doi.org/10.29130/dubited.449055
L1  - https://dergipark.org.tr/en/download/article-file/647138
ER  -