@article{article_451930, title={Assessment of relationship between serum magnesium and serum glucose levels and HOMA-IR in diabetic and prediabetic patients}, journal={Archives of Clinical and Experimental Medicine}, volume={4}, pages={6–9}, year={2019}, DOI={10.25000/acem.451930}, author={Şahingöz Erdal, Gülçin and Karandere, Faruk and Mısıroğlu, Fuat and Özbaş Tevetoğlu, İşıl and Okuturlar, Yıldız and Koçoğlu, Hakan and Hurşitoğlu, Mehmet}, keywords={Magnesium,Diabetes,Prediabetes,Insulin resistance,Fasting glucose,HOMA-IR}, abstract={<p class="Standard" style="margin-bottom:.0001pt;line-height:200%;"> <span style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;">Aim: In this study, we aimed to investigate
the serum magnesium (Mg) levels in diabetic and prediabetic patients and its
correlation with age, body-mass index, HOMA-IR, serum fasting glucose, HbA1c,
and insulin levels. </span> </p> <p> </p> <p class="Standard" style="margin-bottom:.0001pt;line-height:200%;"> <span style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;">Methods: In this retrospective study, a total
of 130 patients consisted of newly diagnosed prediabetes (Group PD) (n=63) and
type 2 diabetes mellitus (Group D) (n=67) were included. Patients’ age, body
mass index, serum Mg, glucose and insulin, HOMA-IR and HbA1c were recorded. The
prediabetes and type 2 diabetes diagnoses had been made according to WHO
criteria at the time of diagnosis. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;">Results: In group D, the mean Mg level (1.88
± 0.17 mg/dl) was significantly lower than group PD (1.96 ± 0.17 mg/dl) (p = 0.007).
Correlation analysis showed that there was a significant negative correlation
between Mg and glucose (r = -0.390, p = 0.001) and HOMA-IR (r = -0.284; p = 0.022)
in the group D. No correlation was found between serum Mg level and serum
insulin, HbA1c, age, and body-mass index (p = 0.801, 0.087, 0.611 and 0.691,
respectively). In group PD, serum insulin, HbA1c, glucose, HOMA-IR, age, and
body-mass index were not corraleted with serum Mg levels (p = 0.801, 0.087, 0.939,
0.998, 0.611 and 0.691, respectively). </span> </p> <p> </p> <p class="Standard" style="text-align:justify;text-indent:35.4pt;line-height:150%;"> <span style="font-size:12pt;line-height:115%;font-family:’Times New Roman’, serif;">Conclusıon: </span> <span style="font-size:12pt;line-height:115%;font-family:’Times New Roman’, serif;">We showed
that while there was a negative correlation between magnesium levels and
HOMA-IR and fasting blood glucose levels in diabetic patients, but this
correlation was not present in prediabetic patients. Our results suggest that
serum Mg level is associated with metabolic control of </span> <span style="font-size:12pt;line-height:115%;font-family:’Times New Roman’, serif;">type 2 diabetes </span> <span style="font-size:12pt;line-height:115%;font-family:’Times New Roman’, serif;"> and thus
it can <a> </a>be considered in these patients. </span> <br /> </p>}, number={1}, publisher={Mustafa HASBAHÇECİ}