TY  - JOUR
T1  - Preparation, Characterization and Drug Release Properties of Polyvinyl Alcohol and Polyvinyl Pyrolidone Blended Hydrogels
TT  - Polivinil Alkol Ve Polivinil Pirolidon Hidrojellerinin Sentezi, Karakterizasyonu Ve İlaç Salım Davranışları
AU  - Taşdelen, Betül
PY  - 2018
DA  - December
JF  - European Journal of Engineering and Applied Sciences
JO  - EJEAS
PB  - Tekirdag Namik Kemal University
WT  - DergiPark
SN  - 2651-3412
SP  - 27
EP  - 30
VL  - 1
IS  - 1
LA  - en
AB  - In this work, a new polyvinyl alcohol (PVA)/polyvinyl pyrrolidone (PVP) /Pumice composite has been synthesized by using gamma rays irradiation technique. The chemical characteristics of the hydrogels were determined by Fourier Transform Infrared Spectroscopy method. The properties of the hydrogels were investigated in terms of swelling, drug uptake and release behaviors. 5-Fluorouracil (5-FU) was used as a model drug for the study of drug uptake and release behaviour of hydrogels. The addition of pumice in the gel structure improved drug uptake and release capability of the new hydrogels.
KW  - Drug
KW  - Hydrogel
KW  - Polyvinyl alcohol
KW  - Polyvinyl pyrrolidone
KW  - Pumice
N2  - Bu çalışmada, yenibir polivinil alkol (PVA) / polivinil pirolidon (PVP)/Pomza kompozit malzemesigama ışınları ile radyasyon tekniği ile sentezlensi. Hidrojellerin kimyasalözellikleri Fourier Transform İnfrared Spektroskopi metotu ile belirlendi. Hidrojellerinşişme,, ilaç emilimi ve salım davranışları incelendi. 5-Fluorurasil (5-FU),hidrojellerin ilaç tutumu ve salım davranışlarının incelenmesinde model ilaçolarak kullanıldı. Pomzanın jel yapısına ilavesi hidrojellerin ilaç tutumu vesalım kapasitesini arttırdı.
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UR  - https://dergipark.org.tr/en/pub/ejeas/article/452989
L1  - https://dergipark.org.tr/en/download/article-file/597016
ER  -