TY - JOUR T1 - Synthesis and Antioxidant Activities of Some Novel 1-(Morpholine-4-il-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones AU - Manap, Sevda AU - Aytemız, Fevzi AU - Yuksek, Haydar PY - 2018 DA - August JF - The Eurasia Proceedings of Science Technology Engineering and Mathematics JO - EPSTEM PB - ISRES Publishing WT - DergiPark SN - 2602-3199 SP - 135 EP - 142 IS - 2 LA - en AB - In this study, 3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones(1) were treated with morpholine in the presence of formaldehyde according tothe Mannich reaction to synthesize five novel1-(morpholine-4-yl-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2). In addition, the antioxidant properties of compounds 2 were analyzed and evaluated using three antioxidant assays,including reducing power, free radical scavenging and metal chelating activity.For the measurement of the reductive ability, Fe3+-Fe2+transformation was investigated in the presence of compound using by the methodof Oyaizu (1986). The hydrogen atoms orelectrons donation ability of the synthesized compound was measured by DPPH. using the method of Blois (1958). The chelating effect of ferrous ions by thecompound was determined according to the method of Dinis, Madeira & Almeida (1994). BHT, BHA, EDTA and α-tocopherolwere used as reference antioxidant compounds. KW - 1 KW - 2 KW - 4-Triazol-5-one KW - Mannich base KW - Antioxidant activity CR - Ali, K. A., Ragab, E. A., Farghaly, T. A., & Abdalla, M. M. (2011). Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents. 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