TY  - JOUR
T1  - Synthesis and Potentiometric Titrations of 3-Alkyl(Aryl)-4-[3-etoxy-4-(4-methoxybenzensulfonyloxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones
AU  - Aktas Yokus, Ozlem
AU  - Beytur, Murat
AU  - Manap, Sevda
AU  - Yuksek, Haydar
PY  - 2018
DA  - August
JF  - The Eurasia Proceedings of Science Technology Engineering and Mathematics
JO  - EPSTEM
PB  - ISRES Publishing
WT  - DergiPark
SN  - 2602-3199
SP  - 143
EP  - 150
IS  - 2
LA  - en
AB  - Determinationof pKa values of theactive constituent of certain pharmaceutical preparations is important becausethe distribution, transport behaviour, bonding to receptors, and contributionsto the metabolic behaviour of the active constituent molecules depend on theionization constant. It is known that 1,2,4-triazole and4,5-dihydro-1H-1,2,4-triazol-5-one rings have weak acidic properties, so thatsome 1,2,4-triazole and 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives weretitrated potentiometrically with tetrabutyl ammonium hydroxide (TBAH) innon-aqueous solvents, and the pKa values of thecompounds were determined. In this study, the first part of the study ninenovel3-alkyl(aryl)-4-[3-etoxy-4-(4-methoxybenzensulfonyloxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesizedfrom the reactions of the corresponding 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones with2-ethoxy-4-formylphenyl 4-methoxybenzenesulfonate, which was obtained from thereaction of 3-ethoxy-4-hydroxybenzaldehyde with 4-methoxybenzensulfonylchloride by using triethylamine. The new compounds synthesized were alsocharacterized by using IR and 1H-NMR, 13C-NMR spectraldata. The second part of the study, nine novel3-alkyl(aryl)-4-[3-etoxy-4-(4-methoxybenzensulfonyloxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones were titratedpotentiometrically with TBAH (tetrabutylammonium hydroxide) in four differentnon-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, acetone and N,N-dimethylformamide) and graphs weredrawn for all cases. The half notralization potentials and pKa values were determined byhalf neutralization method. The effects of solvents and molecular structureupon acidity were also discussed.
KW  - Synthesis
KW  - 4
KW  - 5-dihydro-1H-1
KW  - 2
KW  - 4-triazol-5-one
KW  - TBAH
KW  - pKa
KW  - Half-neutralization method
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UR  - https://dergipark.org.tr/en/pub/epstem/issue//455181
L1  - https://dergipark.org.tr/en/download/article-file/526844
ER  -