TY  - JOUR
T1  - New oral anticoagulants
TT  - Yeni oral antikoagülanlar
AU  - Kandemir, Hüseyin
PY  - 2019
DA  - January
DO  - 10.32322/jhsm.455382
JF  - Journal of Health Sciences and Medicine
JO  - J Health Sci Med /JHSM /jhsm
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2636-8579
SP  - 24
EP  - 29
VL  - 2
IS  - 1
LA  - en
AB  - Oral anticoagulants aremedications that have an important place in the prevention and treatment ofthromboembolic events that can be seen in the course of many diseases today. Warfarin,vitamin K antagonists are the most commonly known and used oral anticoagulants.Drugs known as new oral anticoagulants have emerged due to the difficulties intreatment and follow-up with warfarin. New oral anticoagulants exhibitanticoagulant effects, disrupting the structure and function of some factors inthe coagulation cascade. There are many advantages such as monitorisationrequirement, constant dose use, patient compliance and ease of follow-up.Meta-analyzes of large studies with new oral anticoagulants have shown thatthey are non-inferior from warfarin in the prevention and treatment ofthromboembolic events, and even superior in some cases. Due to the ease of useand advantages of these new agents, they have been rapidly spreading and takingplace in the prevention and treatment of embolism and ischemic events.Therefore, the areas of use of these drugs, the location of treatment,follow-up, possible side effects and most importantly management of bleedingcomplications should be well known and applied.
KW  - New oral anticoagulants
KW  - warfarin
KW  - thromboembolism
KW  - ischemia
KW  - bleeding
N2  - Oral antikoagülanlar günümüzdebirçok hastalığın seyrinde görülebilen tromboembolik olayların engellenmesindeve tedavisinde çok önemli yeri olan ilaçlardır. Varfarin vitamin kantagonistlerinden en çok bilinen ve kullanılan oral antikoagülanlardır.Varfarin ile yapılan tedavi ve takiplerinde görülen zorluklarından dolayı yenioral antikoagülanlar olarak bilinen ilaçlar ortaya çıkmıştır. Yeni oralantikogülanlar, koagülasyon kaskatında bazı faktörlerin yapı ve işlevlerinibozarak antikoagülan etki göstermektedirler. Monitorizasyon gerektirmemesi,sabit dozda kullanımı, hasta uyumu ve takip kolaylığı gibi birçok avantajlarıvardır. Yeni oral antikoagülanlar ile yapılan büyük çalışmaların meta-analizlerinebakıldığında, tromboembolik olaylardan koruma ve tedavisinde varfarindenaşağıda kalmadığı, hatta bazı durumlarda üstün olduğu saptanmıştır. Buajanların kullanım kolaylığı ve avantajlarından dolayı emboli ve iskemikolaylardan korunma ve tedavisinde hızlı bir şekilde yer bulmuş veyaygınlaşmıştır. Bu nedenle bu ilaçların kullanımı, tedavideki yerleri,takipleri, olası yan etkileri ve en önemlisi kanama komplikasyonlarınınyönetimi iyi bilinmeli ve uygulanmalıdır.
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UR  - https://doi.org/10.32322/jhsm.455382
L1  - https://dergipark.org.tr/en/download/article-file/631938
ER  -