@article{article_455942, title={Molecular Investigation of Metallo-β-lactamase Encoding Gene in Nosocomial Carbapenem-Resistant Enterobacteriaceae in Iraqi Hospitals}, journal={The Eurasia Proceedings of Science Technology Engineering and Mathematics}, pages={239–243}, year={2018}, author={S. K. Al-khafajı, Ahmed and Albaayıt, Shaymaa Fadhel Abbas and S. Ibraheem, Omyma and H. Abdul-ılah, Hawraa}, keywords={blaIMP,Enterobacteriaceae,Nosocomial infection,Metallo-β-lactamase}, abstract={<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align: justify;line-height:normal">In recent years, there has been an increasing amount of evidence that nosocomial carbapenem-resistant Enterobacteriaceae pose a major puplic health threat. This study aims to uncover the association of multidrug-resistance related genes with increasing the rate of acquired hospital infections by Enterobacteriaceae pathogens. Enterobacteriaceae species (n=57) were detected in clinical specimens (n=45) obtained from patients with infected wounds and burns in 3 Iraqi hospitals <span lang="EN-GB">. </span> Carbapenem-resistant Enterobacteriaceae bacteria were investigated by antibacterial susceptibility tests.  The Molecular investigation by PCR analysis showed that <i> <span lang="EN-GB">Klebsiella pneumonia </span> </i> <span lang="EN-GB">isolates (n=5) and <i>Escherichia coli </i> isolates (n=3) </span> are carrying metallo-β-lactamase encoding gene ( <i> <span lang="EN-GB">bla </span> </i> <sub> <span lang="EN-GB">IMP </span> </sub>). It can be concluded that the expression of <i> <span lang="EN-GB">bla </span> </i> <sub> <span lang="EN-GB">IMP </span> </sub> is considered among the main reasons of dominating resistance strains of Enterobacteriaceae pathogens and thus spreading nosocomial infection in Iraqi clinical centers. However, further molecular investigation is needed to overcome this resistance on molecular bases when treating. <o:p> </o:p> </p>}, number={2}, publisher={ISRES Publishing}