@article{article_457412, title={Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages}, journal={International Journal of Secondary Metabolite}, volume={5}, pages={319–330}, year={2018}, DOI={10.21448/ijsm.457412}, author={Varol, Mehmet}, keywords={Lichen, Ultraviolet, Photoprotective, Pulvinic Acid, p-value}, abstract={<div style="text-align:justify;"> <span style="font-family:’Times New Roman’, serif;font-size:10pt;">Pulvinic acid derivatives are considered as
worthy to be evaluated as skin protection factor toward ultraviolet-induced
damages because of their colors and locations in lichens. Due to the lack of
literature about photo-protective features of pulvinic acid derivatives, their
cosmetic potentials for skin protection were evaluated </span> <i style="font-family:’Times New Roman’, serif;font-size:10pt;">in silico </i> <span style="font-family:’Times New Roman’, serif;font-size:10pt;">, for the first time. Computational chemistry, biology and
pharmacology platforms such as Gaussian, GAMESS, PASS, PaDEL-DDPredictor and
VEGA QSAR platforms were employed to determine the activities of pulvinic acid
derivatives. Pulvinic acid derivatives were divided into three groups as the
most promising, promising and unpromising compounds according to the calculated </span> <i style="font-family:’Times New Roman’, serif;font-size:10pt;">p- </i> <span style="font-family:’Times New Roman’, serif;font-size:10pt;">values. Although leprapinic acid,
demethylleprapinic acid, pinastric acid, leprapinic acid methyl ether,
4-hydroxyvulpinic acid and vulpinic acid were determined as the most promising
compounds, epanorin and rhizocarpic acid were identified as promising
compounds. The proposed model seems to be reliable because the calculated </span> <i style="font-family:’Times New Roman’, serif;font-size:10pt;">p- </i> <span style="font-family:’Times New Roman’, serif;font-size:10pt;">value for vulpinic acid was found to
be compatible with previously obtained experimental results. The pulvinic acid
derivatives that were identified as the most promising ones should be therefore
further studied by </span> <i style="font-family:’Times New Roman’, serif;font-size:10pt;">in vitro </i> <span style="font-family:’Times New Roman’, serif;font-size:10pt;"> and </span> <i style="font-family:’Times New Roman’, serif;font-size:10pt;">in vivo </i> <span style="font-family:’Times New Roman’, serif;font-size:10pt;"> multiple experiments. </span> </div>}, number={4}, publisher={İzzet KARA}