TY  - JOUR
T1  - Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages
TT  - Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages
AU  - Varol, Mehmet
PY  - 2018
DA  - December
DO  - 10.21448/ijsm.457412
JF  - International Journal of Secondary Metabolite
JO  - Int. J. Sec. Metabolite
PB  - İzzet KARA
WT  - DergiPark
SN  - 2148-6905
SP  - 319
EP  - 330
VL  - 5
IS  - 4
LA  - en
AB  - Pulvinic acid derivatives are considered asworthy to be evaluated as skin protection factor toward ultraviolet-induceddamages because of their colors and locations in lichens. Due to the lack ofliterature about photo-protective features of pulvinic acid derivatives, theircosmetic potentials for skin protection were evaluated in silico, for the first time. Computational chemistry, biology andpharmacology platforms such as Gaussian, GAMESS, PASS, PaDEL-DDPredictor andVEGA QSAR platforms were employed to determine the activities of pulvinic acidderivatives. Pulvinic acid derivatives were divided into three groups as themost promising, promising and unpromising compounds according to the calculatedp-values. Although leprapinic acid,demethylleprapinic acid, pinastric acid, leprapinic acid methyl ether,4-hydroxyvulpinic acid and vulpinic acid were determined as the most promisingcompounds, epanorin and rhizocarpic acid were identified as promisingcompounds. The proposed model seems to be reliable because the calculated p-value for vulpinic acid was found tobe compatible with previously obtained experimental results. The pulvinic acidderivatives that were identified as the most promising ones should be thereforefurther studied by in vitro and in vivo multiple experiments.
KW  - Lichen
KW  - Ultraviolet
KW  - Photoprotective
KW  - Pulvinic Acid
KW  - p-value
N2  - Pulvinic acid derivatives are considered asworthy to be evaluated as skin protection factor toward ultraviolet-induceddamages because of their colors and locations in lichens. Due to the lack ofliterature about photo-protective features of pulvinic acid derivatives, theircosmetic potentials for skin protection were evaluated in silico, for the first time. Computational chemistry, biology andpharmacology platforms such as Gaussian, GAMESS, PASS, PaDEL-DDPredictor andVEGA QSAR platforms were employed to determine the activities of pulvinic acidderivatives. Pulvinic acid derivatives were divided into three groups as themost promising, promising and unpromising compounds according to the calculatedp-values. Although leprapinic acid,demethylleprapinic acid, pinastric acid, leprapinic acid methyl ether,4-hydroxyvulpinic acid and vulpinic acid were determined as the most promisingcompounds, epanorin and rhizocarpic acid were identified as promisingcompounds. The proposed model seems to be reliable because the calculated p-value for vulpinic acid was found tobe compatible with previously obtained experimental results. The pulvinic acidderivatives that were identified as the most promising ones should be thereforefurther studied by in vitro and in vivo multiple experiments.
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UR  - https://doi.org/10.21448/ijsm.457412
L1  - https://dergipark.org.tr/en/download/article-file/579488
ER  -